COVID-19 Pandemic: from Molecular Biology, Pathogenesis, Detection, and Treatment to Global Societal Impact
- PDF / 1,139,683 Bytes
- 16 Pages / 595.276 x 790.866 pts Page_size
- 8 Downloads / 160 Views
CLINICAL PHARMACOLOGY (L BRUNETTI, SECTION EDITOR)
COVID-19 Pandemic: from Molecular Biology, Pathogenesis, Detection, and Treatment to Global Societal Impact Shivani Sood 1 & Vaishali Aggarwal 2 & Diwakar Aggarwal 3 & Sushil K Upadhyay 3 & Katrin Sak 4 & Hardeep Singh Tuli 3 Manoj Kumar 5 & Jayant Kumar 1 & Shivangi Talwar 6
&
# Springer Nature Switzerland AG 2020
Abstract Purpose of Review In December 2019, there was an outbreak of viral disease in Wuhan, China which raised the concern across the whole world. The viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or novel coronavirus or COVID-19 (CoV-19) is known as a pandemic. After SARS-CoV and Middle East respiratory syndrome (MERS)–related CoV, COVID-19 is the third most pathogenic virus, hazardous to humans which have raised worries concerning the capacity of current security measures and the human services framework to deal with such danger. Recent Findings According to WHO, the mortality rate of COVID-19 exceeded that of SARS and MERS in view of which COVID-19 was declared as public health emergency of international concern. Coronaviruses are positive-sense RNA viruses with single stranded RNA and non-segmented envelopes. Recently, genome sequencing confirmed that COVID-19 is similar to SARS-CoV and bat coronavirus, but the major source of this pandemic outbreak, its transmission, and mechanisms related to its pathogenicity to humans are not yet known. Summary In order to prevent the further pandemic and loss to humanity, scientists are studying the development of therapeutic drugs, vaccines, and strategies to cure the infections. In this review, we present a brief introduction to emerging and re-emerging pathogens, i.e., coronavirus in humans and animals, its taxonomic classification, genome organization, its replication, pathogenicity, impact on socioeconomic growth, and drugs associated with COVID-19. Keywords Coronavirus . RNA genomes . SARS-CoV . MERS-CoV
Introduction
This article is part of the Topical Collection on Clinical Pharmacology * Hardeep Singh Tuli [email protected] 1
Department of Biotechnology, Mukand Lal National College, Yamuna Nagar, India
2
Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA
3
Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala 133207, India
4
NGO Praeventio, Tartu, Estonia
5
Department of Chemistry, Maharishi Markandeshwar University, Sadopur 134007, India
6
Amity Institute of Biotechnology, Amity University, Noida, India
Coronaviruses have been studied for more than 50 years and have infected many species of animals, which include birds and humans, and its first reported strain was isolated from the prototype murine coronavirus strain JHM [1]. The increasing population, frequent mixing of animals, deforestation, and urbanization have increased the population of other viruses too along with coronavirus. Coronaviruses belong to the largest group of viruses which are positive-sense RN
Data Loading...
