Crohn's Disease and Ulcerative Colitis From Epidemiology and Immunob
The conditions of Crohn’s disease and ulcerative colitis are excellent examples of how the exponential growth of knowledge in biomedical science can make a remarkable impact on clinical practice and patient’s quality of life. It has led to the devel
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Daniel C. Baumgart Editor
Crohn’s Disease and Ulcerative Colitis From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach
Editor Daniel C. Baumgart Division of Gastroenterology and Hepatology, Department of Medicine, Charité Medical Center – Virchow Hospital Medical School of the Humboldt–University of Berlin Berlin, Germany [email protected]
ISBN 978-1-4614-0997-7 e-ISBN 978-1-4614-0998-4 DOI 10.1007/978-1-4614-0998-4 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011941216 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
The clinical features of the major forms of Inflammatory Bowel Disease, Crohn’s disease and ulcerative colitis, have been generally well-known for decades. After a long period in which advances in our understanding of the causation and pathogenesis of Inflammatory Bowel Diseases remained painfully slow and, in parallel, improvements in management were at best incremental, the momentum of progress has accelerated over the past several years, making a textbook that draws together the full continuum of these timely advances. The recent pace of progress in understanding underlying pathogenesis has been especially remarkable. This has been possible because of more powerful methodological approaches as well as a growing community of investigators focused on these disorders and the basic processes associated with them. Progress in recent years has been rapid along a number of fronts and a general paradigm has emerged to suggest that these disorders result from alterations in the host response to the microflora present within the GI tract. These host responses comprise the collective functional integrity of the mucosal epithelium and the complex set of innate and adaptive immune responses. While many details remain to be fleshed out, molecular pathw
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