CTC with 6mm lesion threshold cost effective for CRC screening
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Parameters: Prevention of CRC (%) Cost/life-year gaineda ($US) ICERb ($US)
FS
OC
CTC-no threshold
CTC-6mm threshold
31.4
40.4
37.8
36.5
7407
9180
7138
4361
118 440
-
dominated 63 900
versus no screening b incremental cost-effectiveness ratio; compared with CTC using 6mm threshold a
The sensitivity of polyps measuring ≥ 6mm would have to fall by 46% and 24% with screening by optical colonoscopy and CTC without threshold, respectively, for these practices to match the cost-effectiveness of CTC with nonreporting of diminutive lesions. * costs were those relating to the screening test, bleeding, perforation and CRC treatment Pickhardt PJ, et al. Cost-effectiveness of colorectal cancer screening with computed tomography colonography: the impact of not reporting diminutive 801081470 lesions. Cancer 109: 2213-2221, No. 11, 1 Jun 2007
1173-5503/10/0535-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
PharmacoEconomics & Outcomes News 25 Aug 2007 No. 535
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