Cutaneous skull metastasis from uterine leiomyosarcoma: a case report
- PDF / 772,963 Bytes
- 4 Pages / 610 x 792 pts Page_size
- 98 Downloads / 207 Views
Open Access
Case report
Cutaneous skull metastasis from uterine leiomyosarcoma: a case report Nikolaos Barbetakis*1, Dimitrios Paliouras1, Christos Asteriou1, Georgios Samanidis1, Athanassios Kleontas2, Doxakis Anestakis3, Kostas Kaplanis4 and Christodoulos Tsilikas1 Address: 1Thoracic Surgery Department, Theagenio Cancer Hospital, A. Simeonidi 2, Thessaloniki, 54007, Greece, 2General Surgery Department, Theagenio Cancer Hospital, A. Simeonidi 2, Thessaloniki, 54007, Greece, 3Pathology Department, Theagenio Cancer Hospital, A. Simeonidi 2, Thessaloniki, 54007, Greece and 4Gynecology Department, Theagenio Cancer Hospital, A. Simeonidi 2, Thessaloniki, 54007, Greece Email: Nikolaos Barbetakis* - [email protected]; Dimitrios Paliouras - [email protected]; Christos Asteriou - [email protected]; Georgios Samanidis - [email protected]; Athanassios Kleontas - [email protected]; Doxakis Anestakis - [email protected]; Kostas Kaplanis - [email protected]; Christodoulos Tsilikas - [email protected] * Corresponding author
Published: 11 May 2009 World Journal of Surgical Oncology 2009, 7:45
doi:10.1186/1477-7819-7-45
Received: 12 January 2009 Accepted: 11 May 2009
This article is available from: http://www.wjso.com/content/7/1/45 © 2009 Barbetakis et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Cutaneous metastases in the facial region occur in less than 0.5% of patients with metastatic cancer. Case presentation: A 52-year-old woman who admitted with a lung and a skull skin nodule is presented. She had a known diagnosis of uterine leiomyosarcoma following an extended total hysterectomy two years ago. Excision biopsy of both nodules revealed metastatic disease. Conclusion: The appearance of a cutaneous nodule in a patient with a history of uterine leiomyosarcoma might indicate a metastatic tumor lesion. Biopsy and immunohistochemistry are essential for correct diagnosis.
Background Leiomyosarcoma is a rare malignant neoplasm composed of cells demonstrating smooth muscle differentiation. Uterine leiomysarcoma accounts for 25–36% of uterine sarcoma and 1% of all malignancies and has a poor prognosis due to a high metastatic recurrence rate. They most commonly arise de novo; however, a minority (5%) may be associated with prior irradiation. The peak incidence occurs in the 30–40 age range and reaches a plateau in the middle age. Uterine leiomyosarcoma usually presents with features of vaginal bleeding (77–95%), pelvic pain (33%), uterine enlargement or a palpable pelvic mass (20–50%) [1].
The commonly reported sites of metastasis from leiomysarcoma are the lung, kidney and liver [2]. Spread to the thyroid, brain, bone, skeletal muscle, heart, parotid gland and the oral cavity have also been reported [3-8]. Uterine leiomyosarcoma should be dis
Data Loading...
