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Treatment failure: case report In a study of patients with lupus nephritis involving evaluation of kidney samples to investigate the presence of ectopic lymphoid structures, a patient [age and sex not stated] was described, who exhibited treatment failure during treatment with cyclophosphamide and mycophenolate for lupus nephritis (LN). The patient, who had a history of systemic lupus erythematosus, was diagnosed with LN. Subsequent evaluation of kidney sample showed presence of ectopic lymphoid structures. The patient had been receiving treatment with mycophenolate [mycofenolate] and cyclophosphamide [dosages and routes not stated] for LN. However, the patient exhibited treatment failure. Therefore, the patient was switched to rituximab resulting in good response and complete remission of LN. Pacucci VA, et al. Tubulo-interstitial infiltrates in lupus nephritis. Annals of the Rheumatic Diseases 79 (Suppl. 1): 1050-1051 (plus poster) abstr. SAT0223, Jun 2020. 803516143 Available from: URL: https://ard.bmj.com/content/79/Suppl_1/1054.1 [abstract]

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Reactions 21 Nov 2020 No. 1831