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Ischaemic retinopathy and optic neuropathy: case report A 72-year-old woman developed ischaemic retinopathy and optic neuropathy following paclitaxel and cyclophosphamide combination chemotherapy for breast carcinoma. The woman, who had breast carcinoma, started receiving paclitaxel and cyclophosphamide combination chemotherapy [dosages and routes not stated] for the breast carcinoma. She was non-diabetic and non-hypertensive. After fifth cycle of the chemotherapy, she presented with binocular sudden loss of vision (no perception of light), that occurred 1 week previously. At presentation, the intraocular pressure was 18mm Hg in the left eye and 16mm Hg in the right eye. An anterior eye examination showed sluggish pupillary reactions to light. A dilated fundus examination revealed bilateral hyperaemic optic disc swelling, pale white oedematous maculae with cherry-red spots and multiple extensive superficial haemorrhages and vascular sheathing. Optical coherence tomography (OCT) of both the eyes revealed macular oedema, oedematous optic discs, sub-retinal fluid and hyper-reflective inner retinal layers, indicating retinal ischaemia. Brain MRI did not reveal any significant pathology. Based on the medical history, clinical features and OCT findings, she was diagnosed with severe ischaemic retinopathy and optic neuropathy, which was suspected to be induced by either paclitaxel or cyclophosphamide or both [times to reaction onsets not stated]. The woman’s next chemotherapy cycle was therefore delayed [outcomes not stated]. Das A, et al. Paclitaxel -and/or cyclophosphamide -induced severe ischaemic retinopathy. Clinical and Experimental Ophthalmology : 6 Sep 2020. Available from: URL: http:/ 803505423 /doi.org/10.1111/ceo.13854

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Reactions 10 Oct 2020 No. 1825