Cyclosporine Improves Sleep Quality in Patients with Atopic Dermatitis
- PDF / 844,138 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 1 Downloads / 223 Views
ORIGINAL RESEARCH
Cyclosporine Improves Sleep Quality in Patients with Atopic Dermatitis Ken-ichi Yasuda . Yozo Ishiuji . Takuro Endo . Katsumi Tanito . Ryoichi Kamide . Yoshimasa Nobeyama . Akihiko Asahina
Received: July 29, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease characterized by eczema and pruritus, and frequently impairs sleep quality. Although cyclosporine improves symptoms of AD, objective evaluation of sleep in patients with AD treated with cyclosporine has not been reported. This study was conducted to elucidate the effects of cyclosporine on sleep quality for patients with AD.
Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12958025. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13555020-00451-2) contains supplementary material, which is available to authorized users. K. Yasuda Y. Ishiuji Y. Nobeyama (&) A. Asahina Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan e-mail: [email protected] T. Endo Sleep Clinic Chofu, Tokyo, Japan K. Tanito Tsukuda River-City Dermatology Clinic, Tokyo, Japan R. Kamide Hihuno Clinic Ningyocho, Tokyo, Japan
Methods: Twelve patients with moderate-tosevere AD were recruited. Nocturnal sleep quality was evaluated for 7 days using a sleep analyzer, which patients wore at the waist before and after cyclosporine was administered at 2.0–4.0 mg/kg per day. Seven parameters of sleep quality were measured before and after cyclosporine administration for a period of 7 days for each patient. Results: The administration of cyclosporine significantly improved total sleep time in four cases, sleep latency in two cases, wake after sleep onset in six cases, number of awakenings in two cases, sleep efficiency in seven cases, number of awakenings for more than 8 min in three cases, and number of position changes recorded every 2 min in three cases. The mean values of sleep latency significantly decreased after cyclosporine administration (P = 0.023). The mean value of sleep efficiency significantly increased after the administration (P = 0.002). Conclusion: Cyclosporine improves sleep quality in patients with moderate-to-severe AD. Keywords: Atopic dermatitis; Pruritus; Quality of life; Sleep
Cyclosporine;
Dermatol Ther (Heidelb)
Key Summary Points Why carry out the study? Effects of cyclosporine on sleep in patients suffering from atopic dermatitis have not been objectively evaluated yet. What was learned from the study? Sleep quality of 12 patients with atopic dermatitis treated with cyclosporine was analyzed by actigraphy, which is an objective analyzer for sleep quality, in this study. Cyclosporine improves sleep quality including sleep latency and sleep efficiency in patients with atopic dermatitis.
DIGITAL FEATURES This article is published with digital features to facilitate understanding of the article. You can access the digital features on the article’s
Data Loading...
