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Listeria monocytogenes meningitis: case report A 19-year-old man developed Listeria monocytogenes meningitis during treatment with cytarabine and idarubicin for myelodysplastic syndrome (MDS). The man was diagnosed with MDS along with trisomy 8 (at the age of 19 years). He had also been diagnosed with extramedullary acute myeloid leukaemia (chloroma), at the age of 18 years. He started receiving remission induction chemotherapy with cytarabine and idarubicin [dosages and routes not stated] since the age of 19 years. However, he developed Listeria monocytogenes meningitis secondary to the chemotherapy. Subsequent genetic testing showed mutated guanine adenine thymine adenine binding protein 2 deficiency. He received conditioning chemotherapy with fludarabine, cyclophosphamide and total body irradiation followed by haploidentical haematopoietic cell transplantation. Post-transplant, he again received cyclophosphamide therapy. He engrafted successfully and attained full donor chimerism. His mild skin graft-versus-host disease was successfully managed with steroids [specific drugs not stated] and verrucosis virtually resolved 9 months after the transplantation [outcome of the reaction not stated]. van Lier YF, et al. Allogeneic hematopoietic cell transplantation in the management of GATA2 deficiency and pulmonary alveolar proteinosis. Clinical Immunology 218: Sep 803497584 2020. Available from: URL: http://doi.org/10.1016/j.clim.2020.108522

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Reactions 22 Aug 2020 No. 1818