Cytokine profiling in anti neutrophil cytoplasmic antibody-associated vasculitis: a cross-sectional cohort study
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Rheumatology International https://doi.org/10.1007/s00296-019-04364-y
INTERNATIONAL
OBSERVATIONAL RESEARCH
Cytokine profiling in anti neutrophil cytoplasmic antibody‑associated vasculitis: a cross‑sectional cohort study Johanna Charlotte Hoffmann1 · Daniel Patschan2 · Hassan Dihazi1 · Claudia Müller1 · Katrin Schwarze1 · Elvira Henze1 · Oliver Ritter2 · Gerhard Anton Müller1 · Susann Patschan1 Received: 8 April 2019 / Accepted: 30 June 2019 © The Author(s) 2019
Abstract ANCA-associated vasculitides (AAV) are severe diseases, potentially affecting lungs, kidney, and other organs. Nevertheless, risk profiling remains difficult. Aim of the current study was to analyze serological characteristics in AAV. The principal goal was to identify diagnostic markers that potentially allow a more sophisticated risk profiling in AAV. AAV subjects were recruited and evaluated for disease activity, disease stage, medication, and laboratory findings. Serum concentrations of the following parameters were measured: IL-1β, IL-6, IL-17 A, IL-17 F, IL-21, IL-22, IL-23, TNF-α, sCD40L, IL-4, IL-10, IL-25, IL-31, IL-33, and INF-γ. A total number of 62 AAV subjects was included in the study (39 females; 23 males). Forty-five subjects were PR3+, 17 subjects showed ANCA specificity for MPO. The majority of all cytokines fell under the lower detection limit of the assay. Serum IL-10 was higher in both, AAV and SSc as compared to controls; it was also higher in early systemic AAV. Serum IL-33 was elevated in AAV and SSc; in AAV, higher levels were found in non-necrotizing GN and RTX untreated subjects. Serum CD40L was raised in AAV as well; higher concentrations were also found in PR3+ and MPO+ patients and early systemic, generalized, and refractory AAV. IL-10 may potentially serve as a marker of early systemic AAV. IL-33 may help to identify subjects with a higher risk for necrotizing GN in AAV. Keywords AAV · Cytokines · VDI · BVAS
Introduction ANCA-associated vasculitides (AAV) are the most frequent types of primary small-vessel vasculitides, according to the revised Chapel Hill consensus conference nomenclature from 2012 [1]. At least three distinct Johanna Charlotte Hoffmann and Daniel Patschan contributed equally to the study.
disorders represent AAV, each characterized by inflammatory damage of small blood vessels including arterioles, capillaries and venules, and each associated with peripheral circulating anti-neutrophil cytoplasmic antibodies (ANCA) of different antigen affinity. Granulomatosis with polyangiitis (GPA) typically affects lung and kidney, accompanied by the formation of granulomas in a locally destroying manner. Numerous other organs may
* Daniel Patschan d.patschan@klinikum‑brandenburg.de
Oliver Ritter o.ritter@klinikum‑brandenburg.de
Johanna Charlotte Hoffmann [email protected]
Gerhard Anton Müller [email protected]‑goettingen.de
Hassan Dihazi [email protected]‑goettingen.de
Susann Patschan [email protected]
Claudia Müller [email protected]
1
Katrin Schwarze katrinsc
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