Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-
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BRIEF REPORT
Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects Yuki Someya . Yoshifumi Tamura . Kageumi Takeno . Saori Kakehi . Takashi Funayama . Yasuhiko Furukawa . Hiroaki Eshima . Keisuke Watanabe . Toshiyuki Kurihara . Toshio Yanagiya . Hideyoshi Kaga . Ruriko Suzuki . Daisuke Sugimoto . Satoshi Kadowaki . Ryuzo Kawamori . Hirotaka Watada Received: May 24, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: Reduced muscle strength is a high risk factor for type 2 diabetes mellitus, and this association is especially strong in non-obese male individuals. However, it remains unclear how reduced muscle strength affects susceptibility to diabetes. We have examined whether lower limb muscle strength is associated with insulin resistance in non-obese Japanese male subjects. Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12696587. Y. Someya Y. Tamura K. Takeno S. Kakehi H. Eshima R. Kawamori H. Watada Sportology Center, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan Y. Tamura (&) K. Takeno T. Funayama Y. Furukawa H. Kaga R. Suzuki D. Sugimoto S. Kadowaki R. Kawamori H. Watada Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan e-mail: [email protected] Y. Tamura Faculty of International Liberal Arts, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan Y. Someya K. Watanabe T. Kurihara T. Yanagiya Graduate School of Health and Sports Science, Juntendo University, 1-1 Hiraga-gakuendai, Inzai City, Chiba 270-1695, Japan
Methods: Measurements from 64 non-diabetic, non-obese, middle-aged Japanese men were analyzed. Insulin sensitivity in muscle was measured using the hyperinsulinemic-euglycemic clamp. Isometric muscle strength of the knee extensor and flexor muscles was evaluated using a dynameter. Results: Lower muscle strength of knee flexors, but not knee extensors, was associated with impaired muscle insulin sensitivity (knee flexor muscles: low, medium, and high strength was 6.6 ± 2.2, 7.3 ± 2.0, and 8.8 ± 2.2 mg/kg per minute, respectively, p for trend \ 0.05; knee extensor muscles: low, medium, and high strength was 7.3 ± 2.5, 7.5 ± 2.2, and 7.8 ± 2.3 mg/kg per minute, respectively, p for trend = 0.73). Knee flexor muscle strength was also identified as an independent determinant of insulin sensitivity in the multiple regression analysis (b = 0.274, p = 0.036). Conclusions: Diminished strength of knee flexor muscles, but not knee extensor muscles, was associated with muscle insulin sensitivity in non-diabetic, non-obese Japanese male subjects. Keywords: Insulin sensitivity; Muscle strength; Non-obese
Diabetes Ther
Key Summary Points The exact mechanisms of impaired muscle strength in persons with type 2 diabetes are still unclear. The aim of this study was to examine whether
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