Design and mechanical properties simulation of fish scale-like intracranial thrombectomy stent
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Traditional Chinese Medicine Hospital of China Three Gorges University, Yichang Hospital of Traditional Chinese Medicine, Yichang 443003, China Department of Geriatrics, The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an 223003, China 3 Faculty of Mechanical and Material Engineering, Huaiyin Institute of Technology, Huai’an 223003, China a) Address all correspondence to these authors. e-mail: [email protected] b) e-mail: [email protected] c) These authors contributed equally to this work and should be considered co-first authors. 2
Received: 23 April 2020; accepted: 11 June 2020
In recent years, intracranial thrombectomy stent has been an important method to treat ischemic stroke caused by acute thrombosis. In this paper, a new intracranial thrombectomy stent with a fish scale-like structure was designed and its mechanical properties were studied by a finite element method. The porosity of all stents was more than 80%. The space occupation ratio (SOR) of the stents increased linearly with the increase of strut thickness, while the strut width had little effect on SOR. The maximum equivalent stress and strain, the directional deformation and overall radial load of the stent decreased with the increase of strut thickness, however, the strut width has little impact on these parameters. The stents with 0.2 mm strut width and the thickness of 0.15 and 0.20 mm had better radial load performance, and the stent with 0.2 mm strut width and 0.15 mm strut thickness had better contact performance with the vessel wall and displayed better flexibility. Therefore, the present study provides a theoretical basis for the design of new intracranial thrombectomy stent.
INTRODUCTION Cerebral stroke, also known as cerebrovascular accident, is a sudden acute cerebrovascular disease with high incidence, disability, and mortality [1, 2], bringing heavy psychological and economic burden to patients. Stroke is a major public health problem, being the third most common cause of death after myocardial infarction and cancer, and the leading cause of adult disability [3]. Cerebral stroke is divided into ischemic and hemorrhagic, of which more than 80% are ischemic stroke, commonly known as cerebral infarction [4]. The mechanism of cerebral infarction is the same as myocardial infarction, which is caused by large or small artery occlusion both intracranial and extracranial; however, the effect of treatment is far less than that of myocardial infarction. In particular, the treatment of acute stroke caused by thrombosis is still a major challenge for cerebrovascular diseases [5]. At present, tissue plasminogen activator (tPA) is often used for early thrombolytic therapy of the patients with acute ischemic stroke (3–4.5 h). However, intravenous thrombolysis alone is not enough for massive thrombus insoluble by tPA and occlusion of large blood vessels; thus, it may not be enough
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to benefit the patient [6, 7]. Currently, for acute cerebral infarction, the recanalization rate of intravenous thr
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