Developing the Patient Health Questionnaire-8 for a greater impact on the quality of life of patients with functional dy
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RESEARCH ARTICLE
Open Access
Developing the Patient Health Questionnaire‑8 for a greater impact on the quality of life of patients with functional dyspepsia compared to Somatic Symptom Scale‑8 Chaoqun Yuan1†, Guizhen Yong2†, Xi Wang1, Ting Xie1, Chunyan Wang1, Yuan Yuan1 and Guobin He1*
Abstract Background: To develop the Patient Health Questionnaire-8 (PHQ-8) as a more reliable approach than the Somatic Symptom Scale-8 (SSS-8), evaluating somatization which might be a critical factor influencing the quality of life (QoL) in patients with functional dyspepsia (FD). Also, the effects of somatization on QoL of FD patients were assessed by these two approaches. Methods: Herein, 612 FD patients completed a questionnaire involving 25 items. 8/25 items were selected to develop the PHQ-8 by four methods of discrete degree, correlation coefficient, factor analysis, and Cronbach’s α coefficient. Reliability and validity of the PHQ-8 and the SSS-8 were compared by principal component and confirmatory factor analyses. The effects of somatization, depression, and anxiety on the Nepean Dyspepsia Index (NDI) for QoL were explored by Pearson’s correlation coefficient and linear regression analysis. Results: The Cronbach’s α coefficient for the PHQ-8 and the SSS-8 was 0.601 and 0.553, respectively, and the cumulative contribution rate of three extracted factors for the developed PHQ-8 and SSS-8 was 55.103% and 51.666%, respectively. Somatization evaluated by the PHQ-8 (r = 0.309, P
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