Development of Glucose Sensor Using Gold Nanoparticles and Glucose-Oxidase Functionalized Tapered Fiber Structure
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Development of Glucose Sensor Using Gold Nanoparticles and Glucose-Oxidase Functionalized Tapered Fiber Structure Qingshan Yang 1 & Xia Zhang 1
&
Santosh Kumar 1 & Ragini Singh 2 & Bingyuan Zhang 1 & Chenglin Bai 1 & Xipeng Pu 3
Received: 5 May 2019 / Accepted: 4 December 2019 # Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Diabetes mellitus is a common health issue in human beings. It is very important to develop a highly selective and sensitive biosensor for the detection of glucose concentration in the human body. The proposed sensor is based on localized surface plasmon resonance (LSPR) technique. An optical tapered fiber structure is used to develop the proposed sensor. Gold nanoparticles (AuNPs) are used to increase the sensitivity of the sensor probe. AuNPs of size ~ 10 nm is synthesized for this purpose. The characterization of AuNPs was performed with the UV-vis spectroscopy, transmission electron microscope (TEM), and scanning electron microscope (SEM). Further, glucose oxidase enzyme is used to increase the selectivity of the sensor. The selectivity of sensor is tested with different analytes such as cholesterol, urea, L-cysteine, ascorbic acid, and galactose that are generally found in the serum. Keywords Glucose . Glucose oxidase . Taper optical fiber . Gold nanoparticles . Localized surface plasmon resonance
Introduction Diabetes mellitus is one of the severe diseases in human beings. The symptom of diabetes mellitus is high blood glucose level that results in complications such as kidney failure and diabetic retinopathy [20]. Glucose sensors have an important role in diabetes diagnosis, food industry, and biotechnology. There are wide advantages of optical fiber-based glucose sensors such as miniature, cost-effectiveness, remote access, and multiplexing ability [25]. There are two types of glucose sensors, i.e., nonenzymatic [5] and enzymatic [3, 10]. Sun et al. [19] developed the nonenzymatic optical fiber glucose sensor that is based on the evanescent wave absorption. Taper optical fiber region was functionalized with poly (phenylboronic * Xia Zhang [email protected] * Santosh Kumar [email protected] 1
Shandong Key Laboratory of Optical Communication Science and Technology, School of Physics Science and Information Technology, Liaocheng University, 252000, Liaocheng, Shandong, China
2
School of Agriculture Science, Liaocheng University, 252000, Liaocheng, Shandong, China
3
School of Materials Science and Engineering, Liaocheng University, 252000, Liaocheng, Shandong, China
acid) (polyPBA) film. The reflected light intensity through sensor probe is increased with the increase in glucose concentration. Zhang et al. [25] proposed a tilted fiber Bragg-gratingbased optical fiber sensor for the detection of hydrogen peroxide (H2O2) and glucose concentration. The experiments were performed for 0 mM to 12 mM glucose concentration in which 500 μl of 10 μM glucose oxidase (GOx) was added in the glucose solution separately during the measurement means; the sens
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