Development of virtual reality visualization model (VRVM) with relative spatiotemporality for visual contents in molecul

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ORIGINAL ARTICLE

Development of virtual reality visualization model (VRVM) with relative spatiotemporality for visual contents in molecular toxicology education Seunghyun Kim1 · Ryoun Heo1 · Yeonji Chung1 · Sunghyo Park1 · Jung Min Kim1 · Michelle P. Kwon1 · Gil‑Hong Park1 · Meyoung‑Kon Kim1 Accepted: 17 November 2020 © The Korean Society of Toxicogenomics and Toxicoproteomics 2020

Abstract Background  Visualizing educational contents makes learning more efficient and effective especially in the area such as molecular toxicology, which is time consuming and intellectually taxing to learn. Objective  A design principle based on cognitive neuroscience was developed for spatiotemporality of information and optimized virtual reality (VR) for molecular toxicology. We modeled VR with the tricarboxylic acid (TCA) cycle, a major working mechanism of several toxic poisons such as fluoroacetate, malonate, arsenite, etc. to improve the effectiveness of education in molecular toxicology for better recall compared to traditional education methods. Results  We devised an educational system and theoretical basis for virtual reality visualization model (VRVM), as integrated research in this area had been insufficient thus far. We found that VRVM has positive effects on learning and memory when teaching complex topics such as molecular toxicology in our previous study. Conclusions  This study has three main components: (1) construction of VR hardware/software (HW/SW) system; (2) creation of VR space design guide; and (3) verification of VRVM spatiotemporality. Consequently, we developed VRVM for the TCA cycle of toxicological mechanism to improve the study habits of medical students in the context of molecular toxicology studies. To continuously expand this approach for future educational applications, up-to-date findings in areas such as cognitive neuroscience and psychology for studying molecular toxicology should be incorporated to strengthen concepts, logic, and physical models of visualization. Keywords  Virtual reality visualization model (VRVM) · Spatiotemporality · Metabolism · Molecular toxicology · Education

Introduction Visualizing educational contents makes learning more efficient and effective especially in the area such as molecular toxicology or biology-related subjects where learning is

Seunghyun Kim and Ryoun Heo contributed equally to this work. * Meyoung‑Kon Kim [email protected] 1



Department of Medical Biochemistry and Molecular Biology, Korea Research Institute of Molecular Medicine and Nutrition, Korea University College and School of Medicine, 73 Korea‑ro, Seongbuk‑gu, Seoul 02841, South Korea

prone to be both time consuming and intellectually taxing for the majority of university school students. Recently, information and communication technology (ICT) was introduced as a major tool for learning. The utilization of virtual reality (VR), which is an advanced information delivery medium, is attracting attention accordingly. VR is a generic term for technologies that act on human sensory organs to c