Diabetes Mellitus A risk factor for Alzheimer's Disease
This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with r
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Yusaku Nakabeppu Toshiharu Ninomiya Editors
Diabetes Mellitus
A risk factor for Alzheimer's Disease
Advances in Experimental Medicine and Biology Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy NIMA REZAEI, Tehran University of Medical Sciences, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Yusaku Nakabeppu • Toshiharu Ninomiya Editors
Diabetes Mellitus A risk factor for Alzheimer’s Disease
Editors Yusaku Nakabeppu Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience Medical Institute of Bioregulation, Kyushu University Fukuoka, Japan
Toshiharu Ninomiya Department of Epidemiology and Public Health, Graduate School of Medical Sciences Kyushu University Fukuoka, Japan
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-981-13-3539-6 ISBN 978-981-13-3540-2 (eBook) https://doi.org/10.1007/978-981-13-3540-2 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Contents
1 Origins of Brain Insulin and Its Function............................................. 1 Yusaku Nakabeppu 2 Epidemiological Evidence of the Relationship Between Diabetes and Dementia............................................................. 13 Toshiharu Ninomiya 3 Molecular Pathophysiology of Insulin Depletion, Mitochondrial Dysfunction, and Oxidative Stress in Alzheimer’s Disease Brain.....
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