Diabetic Neuropathy Clinical Management

In this newly updated, second edition, leading medical specialists critically review for the general practitioner the latest techniques for the clinical management of diabetic neuropathy. These authoritative contributors focus on the practical aspects of

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CONTEMPOR ARY DIABETES ARISTIDIS VEVES, MD, DSc SERIES EDITOR

Diabetic Neuropathy: Clinical Management, Second Edition, edited by Aristidis Veves, MD, DSc, and Rayaz A. Malik, MBChB, PhD, 2007 The Diabetic Foot, Second Edition, edited by Aristidis Veves, MD, DSc, John M. Giurini, DPM, and Frank W. LoGerfo, MD, 2006 The Diabetic Kidney, edited by PEDRO CORTES, MD, AND CARL ERIK MOGENSEN, MD, 2006 Obesity and Diabetes, edited by Christos S. Mantzoros, MD, 2006

DIABETIC NEUROPATHY Clinical Management, Second Edition

Edited by

ARISTIDIS VEVES, MD, DSc Beth Israel Deaconess Medical Center Harvard Medical School Boston, MA and

RAYAZ A. MALIK, MBChB, PhD Manchester Royal Infirmary and University of Manchester, Manchester, UK

© 2007 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 www.humanapress.com All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. The content and opinions expressed in this book are the sole work of the authors and editors, who have warranted due diligence in the creation and issuance of their work. The publisher, editors, and authors are not responsible for errors or omissions or for any consequences arising from the information or opinions presented in this book and make no warranty, express or implied, with respect to its contents. Due diligence has been taken by the publishers, editors, and authors of this book to assure the accuracy of the information published and to describe generally accepted practices. The contributors herein have carefully checked to ensure that the drug selections and dosages set forth in this text are accurate and in accord with the standards accepted at the time of publication. Notwithstanding, as new research, changes in government regulations, and knowledge from clinical experience relating to drug therapy and drug reactions constantly occurs, the reader is advised to check the product information provided by the manufacturer of each drug for any change in dosages or for additional warnings and contraindications. This is of utmost importance when the recommended drug herein is a new or infrequently used drug. It is the responsibility of the treating physician to determine dosages and treatment strategies for individual patients. Further it is the responsibility of the health care provider to ascertain the Food and Drug Administration status of each drug or device used in their clinical practice. The publisher, editors, and authors are not responsible for errors or omissions or for any consequences from the application of the information presented in this book and make no warranty, express or implied, with respect to the contents in this publication. Production Editor: Michele Seugling Cover Illustration: Figure 3, Chapter 17, by Michael Polydefkis, “Punch Skin Biopsy in Diabetic Neuropathy.” Cover design by Karen Schulz For additional c