Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology

This volume provides a practical yet comprehensive guide to manage the shift in the diagnosis of lung cancer from large resections to small samples, including cytology specimens and core biopsies. Specifically, it outlines various available minimally-inva

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Andre Luis Moreira Anjali Saqi Editors

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Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology

Andre Luis Moreira • Anjali Saqi Editors

Diagnosing Non-small Cell Carcinoma in Small Biopsy and Cytology

Editors Andre Luis Moreira, MD, PhD Department of Pathology Memorial Sloan Kettering Cancer Center New York, NY, USA

Anjali Saqi, MD, MBA Department of Pathology and Cell Biology Columbia University Medical Center New York-Presbyterian Hospital New York, NY, USA

ISBN 978-1-4939-1606-1 ISBN 978-1-4939-1607-8 (eBook) DOI 10.1007/978-1-4939-1607-8 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2014950416 © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

Preface

Lung cancer is the leading cause of cancer-related deaths worldwide, but its recognition at an early stage and diagnosis with minimally invasive procedures can decrease morbidity and mortality. In fact, within the past decade, enormous strides to detect, sample, and treat lung cancer have been made. After many years of no clear progress in therapy for lung cancer, the last decade has witnessed a large paradigm shift on the treatment and management of patients with non-small cell lung cancer (NSCLC). Most of th