Diagnosis of coronary artery disease in patients with atrial fibrillation using low tube voltage coronary CT angiography
- PDF / 1,082,056 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 52 Downloads / 240 Views
ORIGINAL PAPER
Diagnosis of coronary artery disease in patients with atrial fibrillation using low tube voltage coronary CT angiography with isotonic low‑concentration contrast agent Yuning Pan1 · Qiuli Huang1 · Yingchao Zhu2 · Xinrong Zou3 · Huimin Chu4 · Xianfeng Du4 · Aijing Li5 · Shizhong Bu2 Received: 3 February 2019 / Accepted: 24 July 2019 © Springer Nature B.V. 2019
Abstract This prospective study evaluated the image quality and accuracy of coronary computed tomography angiography (CCTA) for diagnosing coronary artery disease (CAD) in patients with atrial fibrillation (AF), in which CCTA used adaptive iterative dose reduction (AIDR) with a low tube voltage and low concentration of isotonic contrast agent. Sixty-eight consecutive patients with AF and suspected CAD were equally and randomly apportioned to two groups and underwent CCTA. In the experimental group, the contrast agent was iodixanol (270 mg I/mL), patients were scanned with 100 kV, and reconstruction was by AIDR. In the conventional scanning (control) group, the contrast agent was iopromide (370 mg I/mL), patients were scanned with 120 kV, and reconstruction was by filtered back projection. The image quality, effective radiation dose (E), and total iodine intake of the groups were compared. Thirty-nine patients with coronary artery stenosis later were given invasive coronary angiography (ICA). The groups were similar with regard to mean CT value, noise, and signal-to-noise and contrast-to-noise ratios. The figure of merit of the experimental group was significantly higher than that of the control group, while the E and total iodine were significantly lower. Using ICA as the diagnostic reference, the groups shared similar sensitivity, specificity, and false positive and false negative rates for diagnosing coronary artery stenosis. For determining CAD in patients with AF, CCTA with isotonic low-concentration contrast agent and low-voltage scanning is a feasible alternative that improves accuracy and reduces radiation dose and iodine intake. Keywords Atrial fibrillation (AF) · Computed tomography (CT) · Radiation dose · Contrast medium · Invasive coronary angiography
Introduction
Yuning Pan and Qiuli Huang contributed equally to this work. * Aijing Li [email protected] * Shizhong Bu [email protected] 1
2
Department of Radiology, Ningbo First Hospital, Ningbo 305010, Zhejiang Province, People’s Republic of China Diabetes Research Center, School of Medicine, Ningbo University, 818 Fenghua Road, Jiangbei District, Ningbo 315211, Zhejiang Province, People’s Republic of China
Coronary computed tomography angiography (CCTA) is an effective non-invasive technology to evaluate coronary artery disease (CAD) [1], but arrhythmia will affect the demonstration and evaluation of coronary arteries [2]. In 3
Department of Endocrinology, Li Huili Easton Hospital of Ningbo Medical Center, Ningbo 305040, Zhejiang Province, People’s Republic of China
4
Department of Cardiology, Ningbo First Hospital, Ningbo 305010, Zhejiang Province, People’s R
Data Loading...
