Diagnosis, prevention, and treatment of cardiovascular diseases in people with type 2 diabetes and prediabetes: a consen

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Diagnosis, prevention, and treatment of cardiovascular diseases in people with type 2 diabetes and prediabetes: a consensus statement jointly from the Japanese Circulation Society and the Japan Diabetes Society Eiichi Araki1 · Atsushi Tanaka2 · Nobuya Inagaki3 · Hiroshi Ito4 · Kohjiro Ueki5 · Toyoaki Murohara6 · Kenjiro Imai7 · Masataka Sata8 · Takehiro Sugiyama7 · Hideki Ishii9 · Shunsuke Yamane3 · Takashi Kadowaki10 · Issei Komuro11 · Koichi Node2 on behalf of the directors of the JCS, JDS Received: 17 August 2020 © The Japan Diabetes Society and The Japanese Circulation Society 2020

This statement is based on the “Diagnosis, Prevention, and Treatment of Cardiovascular Diseases in People With Type 2 Diabetes and Pre-Diabetes: A Consensus Statement Jointed from The Japanese Circulation Society and The Japan Diabetes Society” (ISBN978-4-524-22818-8), which was published in Japanese by Nankodo Co., Ltd. (©The Japanese Circulation Society, The Japan Diabetes Society, 2020) and is jointly published in the Circulation Journal (official English journal of the JCS: doi 10.1253/circj.CJ20-0865) and Diabetology International (official English journal of the JDS). * Koichi Node [email protected]‑u.ac.jp 1

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Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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Diabetes and Metabolism Information Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan



Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

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Department of Cardiovascular Medicine, Saga University, 5‑1‑1 Nabeshima, Saga 849‑8501, Japan

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Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan

Department of Cardiovascular Medicine, Tokushima University Graduate School, Tokushima, Japan

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Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Department of Cardiology, Fujita Health University Bantane Hospital, Nagoya, Japan



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Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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Toranomon Hospital, Tokyo, Japan

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Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

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E. Araki et al.

Table of Contents Introduction I. Diagnosis 1. Impaired Glucose Metabolism 2. Cardiovascular Disease 2.1 Atherosclerotic Cardiovascular Diseases (Particularly, Coronary Artery Disease) 2.2 Heart Failure 2.3 Arrhythmia (Atrial Fibrillation) II. Prevention and Treatment 1. Prevention and Treatment of Macroangiopathies (Coronary Artery Disease and Peripheral Artery Disease) in Patients With Impaired Glucose Metabolism 1.1 Lifestyle Intervention 1.1.1 Exercise Therapy 1.1.2 Smoking Cessation and Nutritional, Dietary, and Weight Management 1.2 Pharmacotherapies 1.2.1 Antidyslipidemic, Antihypertensive, and Antiplatelet Drugs 1.2.2 Antidia