Dienogest
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Dienogest Metrorrhagia, abdominal pain, depression and hot flashes: 5 case reports Five women developed adverse reactions, including metrorrhagia, gastralgia, depression and hot flashes, during treatment with oral dienogest 1mg twice daily (2 mg/day) for extragenital endometriosis and associated symptoms [see table for details].
Patient details Pt/age (y)
Site of EEM
1/39
rectosigmoid
2/38
rectosigmoid
3/44 4/48
rectosigmoid rectosigmoid
5/46
bladder
EEM-associated symptoms
Adverse reaction
haematochezia, defecation pain haematochezia, defecation pain defecation pain defecation pain
metrorrhagia
urodynia
metrorrhagia gastralgia, hot flash depression, hot flash, metrorrhagia metrorrhagia
Pt = patient; EEM = extragenital endometriosis
Patients 3 and 4 discontinued dienogest after 10 to 11 months of therapy, after developing gastralgia and depression, respectively. Tolerable metrorrhagia developed in all four patients with a uterus. [Time to onset of reactions not stated; patient outcomes not stated.] Harada M, et al. Dienogest, a new conservative strategy for extragenital endometriosis: A pilot study. Gynecological Endocrinology 27: 717-720, No. 9, Sep 2011. Available from: URL: http://dx.doi.org/10.3109/09513590.2010.533800 803060741 - Japan
0114-9954/10/1371-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Reactions 1 Oct 2011 No. 1371
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