Dietary patterns interact with the variations of 18q21.23 rs17782313 locus on regulation of hypothalamic-pituitary axis
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ORIGINAL ARTICLE
Dietary patterns interact with the variations of 18q21.23 rs17782313 locus on regulation of hypothalamic‑pituitary axis hormones and cardio‑metabolic risk factors in obesity Mohaddeseh Mohammadi1 · Mahdieh Khodarahmi2 · Houman Kahroba3 · Mahdieh Abbasalizad Farhangi4 Received: 8 October 2019 / Accepted: 21 January 2020 © Springer Nature Switzerland AG 2020
Abstract Background Evidence shows the role of polymorphisms in rs17782313 MC4R gene with increased risk of obesity in Asians adult. In the current report, we investigated the interaction between rs17782313 MC4R gene and major dietary patterns on α-melanocyte stimulating hormone (α-MSH), Agouti-related peptide (AgRP), serum lipids and blood pressure among obese individuals. Methods This cross-sectional study was performed in 288 obese adults between 20 and 50 years of age. Anthropometric measurements and biochemical assays were conducted with standard methods. To evaluate appetite, the Visual Analogue Scale (VAS) was used. Dietary patterns were obtained by principal component analysis (PCA). Genotyping of rs17782313 was assessed by restriction fragment length polymorphism (PCR–RFLP) method. Results Three major dietary patterns were extracted: Prudent Dietary Pattern (PDP), Legume Dietary Pattern (LDP) and Mixed Dietary Pattern (MDP). Higher PDP score was associated with reduced SBP and insulin concentration while highest MDP score was associated with lower TG concentration (P
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