Differences in men and women suffering from CRSwNP and AERD in quality of life
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RHINOLOGY
Differences in men and women suffering from CRSwNP and AERD in quality of life Tina J. Bartosik1 · David T. Liu1 · Nicholas J. Campion1 · Sergio Villazala‑Merino1 · Stefan Janik1 · Valerie Dahm1 · Christian A. Mueller1 · Erich Vyskocil1 · Victoria Stanek1 · Tamara Quint2 · Christine Bangert2 · Julia Eckl‑Dorna1 · Sven Schneider1 Received: 10 September 2020 / Accepted: 3 October 2020 © The Author(s) 2020
Abstract Purpose While the overall impact of chronic rhinosinusitis (CRS) on patients’ health is diverse, many affected individuals have a substantially impaired quality of life (QoL). The aim of this study was to evaluate the impact of sex-associated differences specifically in the subgroups of CRS with nasal polyps (CRSwNP) and aspirin-exacerbated respiratory disease (AERD) by assessing QoL parameters in women and men separately. Methods In a retrospective single-center study, 59 patients with CRSwNP (39 males and 20 females) and 46 patients with AERD (18 males and 28 females) were included. Patient-reported outcome measures (PROM) evaluating QoL via the SinoNasal Outcome Test-20 German Adapted Version (SNOT-20 GAV) as well as the total polyp score (TPS) were analysed. Results There was no significant difference in TPS (p = 0.5550) and total SNOT-20 GAV scores (p = 0.0726) between male or female patients with CRSwNP or AERD. Furthermore, no significant sex differences were found within disease groups regarding the subcategories of the SNOT-20 GAV items. Conclusion Thus, quality of life is severely impaired in patients suffering from various forms of CRS regardless of their sex. Keywords Chronic rhinosinusitis · Sex · Polyps · Aspirin-exacerbated respiratory disease · AERD · Samter’s triad · SNOT20 GAV
Introduction Sex- and gender-related factors are present in a variety of diseases affecting the clinical presentation and treatment of these medical conditions, as well as the impact on patients’ quality of life (QoL) [1]. Among others, sex-related aspects have not only been identified regarding genetics and hormones, but interestingly also when analysing epigenetics, immune function, aging including neurocognitive decline, vascular status as well as response to therapeutics and interaction with the health care system [2]. Chronic rhinosinusitis (CRS) is a common, yet diverse disease affecting 4–16% of the general population [3–5]. * Julia Eckl‑Dorna julia.eckl‑[email protected] 1
Department of Otorhinolaryngology, Medical University of Vienna, Währinger Gürtel 18‑20, 1090 Vienna, Austria
Department of Dermatology, Medical University of Vienna, Währinger Gürtel 18‑20, 1090 Vienna, Austria
2
According to the recently published current version of the European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS 2020), the condition should be classified into primary and secondary CRS. While the former is associated with generalized inflammation, the latter is caused by other underlying triggers including tumours, odontogenic reasons, or fungal growth. Primary CRS can be further
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