Different Performance of Liver Stiffness Measurement According to Etiology and Outcome for the Prediction of Liver-Relat
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ORIGINAL ARTICLE
Different Performance of Liver Stiffness Measurement According to Etiology and Outcome for the Prediction of Liver‑Related Events Joo Hyun Oh1 · Myung Ji Goh1 · Yewan Park1 · Jihye Kim1 · Wonseok Kang1 · Dong Hyun Sinn1 · Geum‑Youn Gwak1 · Moon Seok Choi1 · Joon Hyeok Lee1 · Kwang Cheol Koh1 · Seung Woon Paik1 · Yong‑Han Paik1 Received: 18 May 2020 / Accepted: 26 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background/Aims Liver stiffness measurement (LSM) by transient elastography (TE) has shown promising results for prediction of hepatocellular carcinoma (HCC) and hepatic decompensation in patients with chronic liver disease (CLD). However, whether prognostic performance of TE differs according to etiology or type of outcome remains further clarification. Methods Performance of LSM for the prediction of HCC and hepatic decompensation was analyzed in a cohort of 4026 patients with asymptomatic CLD. Results During median 4.5 years of follow-up (range 3.0–6.2 years), liver-related events (LRE) were observed in 196 patients (166 with HCC, 45 with hepatic decompensation, and 15 with both). In the multivariate analysis, LSM was independent factor associated with LRE and showed high AUROC (0.78). When stratified by type of outcome and etiology of liver disease, LSM showed high AUROC for the prediction of HCC for patients with non-viral hepatitis (0.89), while it showed relatively low AUROC for the prediction of HCC for patients with viral hepatitis (0.75). For the prediction of hepatic decompensation, LSM showed high AUROC for patients with both viral- and non-viral hepatitis (0.90, 0.90, respectively). Conclusions LSM showed powerful prognostic role for the prediction of LRE in patients with CLD. Notably, HCC risk was not negligible in patients with viral hepatitis who showed LSM value
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