Differential Expression of a Set of Genes in Follicular and Classic Variants of Papillary Thyroid Carcinoma
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Differential Expression of a Set of Genes in Follicular and Classic Variants of Papillary Thyroid Carcinoma Yusuf Ziya Igci & Ahmet Arslan & Ersin Akarsu & Suna Erkilic & Mehri Igci & Serdar Oztuzcu & Beyhan Cengiz & Bulent Gogebakan & Ecir Ali Cakmak & A. Tuncay Demiryurek
Published online: 21 April 2011 # Springer Science+Business Media, LLC 2011
Abstract Fine-needle aspiration biopsy (FNA) is currently the best initial diagnostic test for evaluation of a thyroid nodule. FNA cytology cannot discriminate between benign and malignant thyroid nodules in up to 30% of thyroid nodules. Therefore, an adjunct to FNA is needed to clarify these lesions as benign or malignant. Using differential display-polymerase chain reaction method, the gene expression differences between follicular and classic variants of papillary thyroid carcinoma (PTC) and benign thyroid nodules were evaluated in a
Y. Z. Igci (*) : A. Arslan : M. Igci : S. Oztuzcu : B. Gogebakan : E. A. Cakmak Department of Medical Biology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey e-mail: [email protected] E. Akarsu Department of Endocrinology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey S. Erkilic Department of Pathology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey B. Cengiz Department of Physiology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey A. T. Demiryurek Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
group of 42 patients. Computational gene function analyses via Cytoscape, FuncBASE, and GeneMANIA led us to a functional network of 17 genes in which a core sub-network of five genes coexists. Although the exact mechanisms underlying in thyroid cancer biogenesis are not currently known, our data suggest that the pattern of transformation from healthy cells to cancer cells of PTC is different in follicular variant than in classic variant. Keywords Papillary thyroid carcinoma . Follicular variant of papillary thyroid carcinoma . Classic variant of papillary thyroid carcinoma . Differential display–polymerase chain reaction . GeneMANIA
Introduction Thyroid cancer occurs as a result of somatic or germinal mutations, and accounts for approximately 1% of all cancer cases [1]. Thyroid neoplasms can originate from follicular cells (differentiated or undifferentiated carcinoma), from the parafollicular C cells (medullary thyroid carcinoma), or other forms of thyroid cancer cells [2]. Follicular-cell-originating carcinomas including papillary (papillary thyroid carcinoma (PTC)), follicular (FTC), or oncocytic comprise approximately 90% of all thyroid cancers [2]. PTC is the dominating type among all thyroid malignancies with an approximate frequency of 80% [3]. Although numerous variants of PTC are recognized, one of the most common and diagnostically challenging is the follicular variant [2]. These tumors may be encapsulated or non-encapsulated, and are composed almost exclusively of follicles having the characteristic nuclear f
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