Dissociable dopaminergic and pavlovian influences in goal-trackers and sign-trackers on a model of compulsive checking i
- PDF / 1,445,527 Bytes
- 13 Pages / 595.276 x 790.866 pts Page_size
- 6 Downloads / 199 Views
ORIGINAL INVESTIGATION
Dissociable dopaminergic and pavlovian influences in goal-trackers and sign-trackers on a model of compulsive checking in OCD D. M. Eagle 1 & C. Schepisi 1,2 & S. Chugh 1 & S. Desai 1 & S. Y. S. Han 1 & T. Huang 1 & J. J. Lee 1,3,4 & C. Sobala 1 & W. Ye 1,5 & A. L. Milton 1 & T. W. Robbins 1 Received: 7 May 2020 / Accepted: 7 August 2020 # The Author(s) 2020
Abstract Rationale Checking is a functional behaviour that provides information to guide behaviour. However, in obsessive-compulsive disorder (OCD), checking may escalate to dysfunctional levels. The processes underpinning the transition from functional to dysfunctional checking are unclear but may be associated with individual differences that support the development of maladaptive behaviour. We examined one such predisposition, sign-tracking to a pavlovian conditioned stimulus, which we previously found associated with dysfunctional checking. How sign-tracking interacts with another treatment with emerging translational validity for OCD-like checking, chronic administration of the dopamine D2 receptor agonist quinpirole, is unknown. Objectives We tested how functional and dysfunctional checking in the rat observing response task (ORT) was affected by chronic quinpirole administration in non-autoshaped controls and autoshaped animals classified as sign-trackers or goal-trackers. Methods Sign-trackers or goal-trackers were trained on the ORT before the effects of chronic quinpirole administration on checking were assessed. Subsequently, the effects on checking of different behavioural challenges, including reward omission and the use of unpredictable reinforcement schedules, were tested. Results Prior autoshaping increased checking. Sign-trackers and goal-trackers responded differently to quinpirole sensitization, reward omission and reinforcement uncertainty. Sign-trackers showed greater elevations in dysfunctional checking, particularly during uncertainty. By contrast, goal-trackers predominantly increased functional checking responses, possibly in response to reduced discrimination accuracy in the absence of cues signalling which lever was currently active. Conclusions The results are discussed in terms of how pavlovian associations influence behaviour that becomes compulsive in OCD and how this may be dependent on striatal dopamine D2 receptors. Keywords Obsessive-compulsive disorder . Sign-tracking . Goal-tracking . Quinpirole . Pavlovian . Rat
D. M. Eagle is deceased Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00213-020-05636-3) contains supplementary material, which is available to authorized users. * A. L. Milton [email protected] 1
Department of Psychology, University of Cambridge, Downing Site, Cambridge CB2 3EB, UK
2
Sapienza University of Rome, Rome, Italy
3
University of Bristol, Bristol, UK
4
University College London, London, UK
5
Oxford University Clinical Academic Graduate School, University of Oxford, Oxford, UK
Introduction Checking is a functional response t
Data Loading...
