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Distigmine-bromide Miosis and bradycardia: 2 case reports

A retrospective cohort study of 93 patients, who underwent measurement of serum cholinesterase (sChE) levels between 2011 and 2018 at Kaetsu hospital, Japan, 2 patients [ages and sexes not stated] were described, who developed miosis (one patient) and bradycardia (one patient) during treatment with distigmine bromide [distigmine] for underactive bladder. Subsequently, distigmine bromide was stopped in both patients [routes, dosages, durations of treatments to reactions onsets and outcomes not stated]. Mitsuboshi S, et al. Effect of patient age, dose, and chronic kidney disease on the risk of adverse reactions to distigmine. Biological and Pharmaceutical Bulletin 43: 1275-1278, No. 8, Jan 2020. Available from: URL: http://doi.org/10.1248/BPB.B20-00216

0114-9954/20/1830-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved

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Reactions 14 Nov 2020 No. 1830