Distinct Effects of Social Stress on Working Memory in Obsessive-Compulsive Disorder
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ORIGINAL ARTICLE
Distinct Effects of Social Stress on Working Memory in Obsessive-Compulsive Disorder Qianqian Li1,2 • Jun Yan1,2 • Jinmin Liao1,2 • Xiao Zhang1,2 • Lijun Liu1,2 Xiaoyu Fu1,2 • Hao Yang Tan5,6 • Dai Zhang1,2,3,4 • Hao Yan1,2
•
Received: 12 December 2019 / Accepted: 13 May 2020 Ó The Author(s) 2020
Abstract Stress might exaggerate the compulsion and impair the working memory of patients with obsessivecompulsive disorder (OCD). This study evaluated the effect of stress on the cognitive neural processing of working memory in OCD and its clinical significance using a ‘‘number calculation working memory’’ task. Thirty-eight patients and 55 gender- and education-matched healthy controls were examined. Stress impaired the performance of the manipulation task in patients. Healthy controls showed less engagement of the medial prefrontal cortex Qianqian Li and Jun Yan have contributed to this work.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12264-020-00579-3) contains supplementary material, which is available to authorized users. & Dai Zhang [email protected] & Hao Yan [email protected] 1
Peking University Sixth Hospital, Beijing 100191, China
2
Peking University Institute of Mental Health, National Health Commission Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China
3
Tsinghua University-Peking University Joint Center for Life Sciences, Beijing 100871, China
4
PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China
5
Lieber Institute for Brain Development, Baltimore, MD 21205, USA
6
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
and striatum during the task under stress versus less stress, which was absent in the patients with OCD. The diagnosis 9 stress interaction effect was significant in the right fusiform, supplementary motor area, precentral cortex and caudate. The failure of suppression of the medial prefrontal cortex and striatum and stress-related hyperactivation in the right fusiform, supplementary motor area, precentral cortex, and caudate might be an OCD-related psychopathological and neural response to stress. Keywords Working memory Acute stress Obsessivecompulsive disorder Functional magnetic resonance imaging
Introduction Obsessive-compulsive disorder (OCD) is a chronic and disabling mental disease [1, 2] characterized by the presence of obsessions (repeated thoughts) or compulsions (repeated behaviors to neutralize anxiety), or both [3]. The World Health Organization ranks it as one of the ten most disabling conditions by lost income and reduced quality of life [4]. Stress is one of the main risk factors for the formation of the disorder [5], and previous studies have indicated that OCD patients have an impaired stress response [6]. The neuropsychological th
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