Disulfiram Its Use in Alcohol Dependence and Other Disorders
This book focuses on the value of supervised Disulfiram therapy, highlighting the many potential and unique benefits of Disulfiram. One of the oldest drugs available for the long-term management of alcohol dependence, Disulfiram remains a viable treatment
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Disulfiram
Avinash De Sousa
Disulfiram Its Use in Alcohol Dependence and Other Disorders
Avinash De Sousa Department of Psychiatry Lokmanya Tilak Muncipal Medical College Mumbai India
ISBN 978-981-32-9875-0 ISBN 978-981-32-9876-7 (eBook) https://doi.org/10.1007/978-981-32-9876-7 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
This is a unique and one of its kind book dedicated to a drug named Disulfiram, which has been used in the management of alcohol dependence for the past six decades. The book has eight chapters and traces the history of evolution of Disulfiram, its mechanism of action, its role in alcohol and cocaine dependence, its side effects and toxicity, its use in special populations and its future with certain ethical issues. The book will serve to help clinicians and students alike in understanding various facets of Disulfiram and its usage. This book is dedicated to my late father Prof. Dr. Alan De Sousa who introduced me to Disulfiram and with whom my early work in Disulfiram is associated. I am sure readers will enjoy reading the book as much I have enjoyed writing it. Mumbai, India
Avinash De Sousa
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Contents
1 Disulfiram: The History Behind the Molecule������������������������������������������ 1 1.1 Introduction������������������������������������������������������������������������������������������ 1 1.2 Early History of Disulfiram������������������������������������������������������������������ 2 1.3 Disulfiram as a Pharmacological Agent������������������������������������������������ 2 1.4 Disulfiram and the Name ‘Antabuse’������������������������
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