Does Side Really Matter? Survival Analysis among Patients with Right- Versus Left-Sided Colon Cancer: A Propensity Score
- PDF / 438,839 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 26 Downloads / 198 Views
ORIGINAL ARTICLE – COLORECTAL CANCER
Does Side Really Matter? Survival Analysis among Patients with Right- Versus Left-Sided Colon Cancer: A Propensity ScoreAdjusted Analysis Johannes Klose, MD1,2, Matthias Kloor, MD3, Rene´ Warschkow, MD4, Pia Antony, MD2, Lukas F. Liesenfeld, MD2, Markus W. Bu¨chler, MD2, Martin Schneider, MD2, and Ignazio Tarantino, MD2,4 1
Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany; 2Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany; 3Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany; 4Department of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen, St. Gallen, Switzerland
ABSTRACT Background. Right- and left-sided colon cancer are increasingly regarded as two independent disease entities based on different gene expression profiles as well as underlying genetic mutations. Data regarding prognosis and survival are heterogeneous and more favorable in cases of left-sided colon cancer. Objective. The purpose of this study was to evaluate the long-term oncological outcome for patients with left-sided versus right-sided stage I–III colon cancer. Methods. Overall, 318 consecutive patients who underwent surgery for right- or left-sided sided colon cancer between 2001 and 2014 were analyzed. Analysis was performed applying a prospectively maintained database with respect to overall, disease-specific, and relative survival, using Cox regression and propensity score analyses. Results. A total of 155 patients (48.7%) presented with right-sided colon cancer and 163 patients (51.3%) presented with left-sided colon cancer. In risk-adjusted Cox regression analysis, tumor location had no significant impact on overall survival (hazard ratio [HR] 1.53, 95% confidence interval [CI] 0.80–2.92; p = 0.197), diseasespecific survival (HR 1.36, 95% CI 0.76–2.44; p = 0.301),
Ó Society of Surgical Oncology 2020 First Received: 31 March 2020 Accepted: 11 August 2020 J. Klose, MD e-mail: [email protected]
and relative survival (HR 1.70, 95% CI 0.89–3.27; p = 0.107). After propensity score matching, the results from risk-adjusted Cox regression analysis were confirmed. Stratified by American Joint Committee on Cancer stage, patients with right-sided stage II colon cancer had a statistically significant superior relative survival compared with patents with left-sided colon cancer. Conclusions. No significant negative impact on overall, disease-specific, or relative survival could be observed in patients with right- versus left-sided colon cancer after risk adjustment, using multivariable Cox regression and propensity score analyses. Keywords Colon cancer Left-sided Right-sided Survival Microsatellite status Propensity score analysis INTRODUCTION Colon cancer remains the third most common type of cancer and cause of cancer-related deaths in the We
Data Loading...
