Does systemic inflammation play a role in patients with pterygium?
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ORIGINAL PAPER
Does systemic inflammation play a role in patients with pterygium? Deniz Kilic
. Soner Guven
Received: 18 February 2020 / Accepted: 2 May 2020 Ó Springer Nature B.V. 2020
Abstract Purpose To compare parameters of systemic inflammation and serum lipid levels in patients with pterygium versus healthy individuals. Methods Thirty-five patients with pterygium and 30 healthy individuals were enrolled as two respective groups in a retrospective study. The participants’ complete blood count (CBC) parameters and levels of serum total cholesterol, low-density lipoprotein, highdensity lipoprotein (HDL), and triglycerides (TG) were obtained from digital records and compared. Their neutrophil/lymphocyte, platelet/lymphocyte, and monocyte/HDL ratios were calculated and compared as well. As secondary outcomes, longitudinal length (LL), basal length (BL), and total area (TA) of pterygium among the patients were quantitatively measured by using ImageJ software. Correlations between serum parameters and pterygium measurements were analyzed. Results Although between-group differences in CBC parameters and the ratios were not statistically significant, HDL levels were significantly lower (p = 0.014) and TG levels significantly higher
D. Kilic (&) S. Guven Department of Ophthalmology, Kayseri City Training and Research Hospital, Health Science University, 38001 Kayseri, Turkey e-mail: [email protected] S. Guven e-mail: [email protected]
(p = 0.031) among patients with pterygium than among the controls. A positive correlation was detected between the patient’s age and the pterygium’s BL (p = 0.002, r = 0.516), LL (p = 0.00, r = 0.547), and TA (p = 0.00, r = 0.515). Neutrophil levels negatively correlated with LL (p = 0.025, b = - 0.308) and TA (p = 0.002, b = - 0.420). Conclusion Local instead of systemic inflammation should be considered in the management of pterygium. Besides, decreased HDL levels may indicate systemic oxidative stress in patients with the condition. Keywords Complete blood count ImageJ Pterygium Serum lipid levels Systemic inflammation
Introduction Pterygium is a common disease of the anterior eye in which fibrovascular tissue grows abnormally on the clear cornea which ranges widely from 2.8 to 33.0% [1–3]. The most common known predisposing factors are exposure to ultraviolet (UV) irradiation (i.e., 400–290 nm) and low concentrations of moisture [4, 5]. Although debate persists on the exact pathophysiology of pterygium, local inflammatory mediators and products of oxidation are generally thought to be responsible [6–8]. However, there should be some
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other systemic or local causes such as an increased systemic inflammation/oxidation or a decreased defensive mechanism for inflammation/oxidation [9]. Recently, the presence of systemic inflammation can now be determined with inexpensive, easily administered tests such as complete blood count (CBC) and biochemical analyses [10, 11]. Moreover, data provided by t
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