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Focal corneal decompensation: case report A 25-year-old man, who was receiving dorzolamide [duration of treatment not clearly stated], developed focal corneal decompensation after undergoing trabeculectomy with mitomycin augmentation. The man was diagnosed with bilateral granulomatous uveitis and left-sided ocular hypertension in 1999, and started receiving timolol; later, additional therapy with dorzolamide eyedrops [dosage not stated] three times daily became necessary to control his intraocular pressure (IOP). In May 2003, he presented with a painful eye and a left visual acuity (VA) of counting fingers at 2 metres. His left IOP was 38mm Hg despite timolol and dorzolamide therapy; the cupto-disc ratio was 0.6 × 0.6 in his left eye and his visual field was significantly constricted. Fundus examination showed macular oedema with cystic changes, and open angles in both eyes. He underwent left trabeculectomy with mitomycin augmentation in June 2003; after dissection of the Tenon capsule, 0.02% mitomycin [dosage not stated] was applied for 1 minute. Postoperatively, his anterior chamber was deep, his IOP decreased to 8mm Hg and his bleb remained functional. However, the inferior third of the cornea gradually became opaque and oedematous [time to reaction onset not stated]. In May 2004, the inferior cornea showed stromal and epithelial oedema and was completely decompensated; corneal thickness was 720µm in the inferior cornea and 550µm in the central cornea. [Patient outcome not stated]. Author comment: "Our patient had received dorzolamide for 1 year before surgery . . . and this medication may have a contributory role in the final endothelial decompensation." Mohammadpour M, et al. Focal corneal decompensation after filtering surgery with 801079744 mitomycin C. Cornea 26: 1285-1287, No. 10, 1 Dec 2007 - Iran

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Reactions 2 Feb 2008 No. 1187