Drug-Induced Liver Toxicity
This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six
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Minjun Chen Yvonne Will Editors
Drug-Induced Liver Toxicity
Methods
in
Pharmacology
and
Series Editor Y. James Kang Department of Pharmacology & Toxicology University of Louisville Louisville, Kentucky, USA
For further volumes: http://www.springer.com/series/7653
Toxicology
Drug-Induced Liver Toxicity Edited by
Minjun Chen Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA
Yvonne Will Drug Safety Research and Development, Pfizer Inc., Groton, CT, USA
Editors Minjun Chen Division of Bioinformatics and Biostatistics National Center for Toxicological Research U.S. Food and Drug Administration Jefferson, AR, USA
Yvonne Will Drug Safety Research and Development Pfizer Inc. Groton, CT, USA
ISSN 1557-2153 ISSN 1940-6053 (electronic) Methods in Pharmacology and Toxicology ISBN 978-1-4939-7676-8 ISBN 978-1-4939-7677-5 (eBook) https://doi.org/10.1007/978-1-4939-7677-5 Library of Congress Control Number: 2018930875 © Springer Science+Business Media, LLC, part of Springer Nature 2018, corrected publication 2018 Chapter 30 is licensed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/). For further details see license information in the chapter. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Foreword I am honored to have been asked to help introduce this unique monograph on a subject that has inspired and piqued my clinical and research interest for more than 35 years. Having been mentored in drug-induced liver injury (DILI) by the late Hyman J Zimmerma
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