Dynamic alterations of spontaneous neural activity in patients with amyotrophic lateral sclerosis
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ORIGINAL RESEARCH
Dynamic alterations of spontaneous neural activity in patients with amyotrophic lateral sclerosis Xujing Ma 1 & Fengmei Lu 2 & Caihong Hu 1 & Jiao Wang 1 & Sheng Zhang 1 & Shuqin Zhang 1 & Guiran Yang 1 & Jiuquan Zhang 3,4 Accepted: 21 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Amyotrophic lateral sclerosis (ALS) is a multi-system disease featured by movement disorder. Studies on ALS using static neuroimaging indexes demonstrated inconsistent results. However, recent work indicated that the intrinsic brain activity was time-varying, and the abnormal temporal dynamics of brain activity in ALS remains unknown. Resting-state functional magnetic resonance imaging data were first obtained from 54 patients with ALS and 54 healthy controls (HCs). Then the dynamic regional homogeneity (d-ReHo) was calculated and compared between the two groups. Correlation analyses between altered d-ReHo and clinical scores were further performed. Compared with HCs, ALS patients showed higher d-ReHo in the left lingual gyrus while lower d-ReHo in the left rectus gyrus and left parahippocampal gyrus. Moreover, the d-ReHo in the left lingual gyrus exhibited correlation with disease progression rate in ALS at a trend level. Our findings suggested that altered dynamics in intrinsic brain activity might be a potential biomarker for diagnosing of ALS. Keywords Amyotrophic lateral sclerosis . Dynamic regional homogeneity . Resting-state functional magnetic resonance imaging . Biomarker
Introduction Amyotrophic lateral sclerosis (ALS) is featured by progressive motor deficits that is developed within weeks or months (van Es et al. 2017). It is considered that nearly half of ALS patients are accompanied with cognitive or behavioral deficits (Ringholz et al., 2005a, b). To date, there is no effective
therapy for ALS due to the lack of knowledge of its pathogenesis. Although the exact mechanism of ALS remains still largely unclear, the development in neuroimaging provides convenience for expanding our understanding. Magnetic resonance imaging (MRI) has been extensively applied to study ALS in vivo and, a series of achievements have been gained. Differences in brain structures including cortical thickness of
Xujing Ma and Fengmei Lu contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11682-020-00405-4) contains supplementary material, which is available to authorized users. * Guiran Yang [email protected]
3
Department of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing 400030, People’s Republic of China
4
Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing 400044, People’s Republic of China
* Jiuquan Zhang [email protected] 1
Department of Medical Technology, Cangzhou Medical C
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