Dynamic Constitutional Membranes: Toward an Adaptive Facilitated Transport
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Dynamic constitutional membranes-toward an adaptive facilitated transport Mihail Barboiu* Adaptative Supramolecular Nanosystems Group, Institut Européen des Membranes, ENSCM/ UMII/UMR-CNRS5635, Place Eugène Bataillon CC047, 34095 Montpellier Cedex 5, France. E-mail: [email protected] ABSTRACT Dynamic Interactive Systems are defined by networks of continuously exchanging and reversibly reorganizing connected objects (supermolecules, polymers, biomolecules, pores, nanoplatforms, surfaces, liposomes, cells). They are operating under the natural selection to allow spatial / temporal and structural / functional adaptability in response to internal constitutionalor to stimulant external factors. In this minireview we will disscuss some selected examples of organic/inorganic SYSTEMS MATERIALS, covering a) the sol-gel resolution of constitutional architectures from Dynamic combinatorial libraries and b) the generation of Dynamic Hybrid Materials and SYSTEMS MEMBRANES able to evolve insidepore architectures via ionic stimuli so as to improve membrane transport functions. INTRODUCTION Constitutional Dynamic Chemistry (CDC) [1] and its application Dynamic Combinatorial Chemistry (DCC) [2] are new evolutional approaches to produce chemical diversity. In contrast to the stepwise methodology of classic combinatorial chemistry, DCC allows for the simple generation of diverse interexchanging architectures from sets of building molecules interacting reversibly. With the DCC approach, the building library elements are spontaneously assembled to form all possible virtual combinations. If libraries are produced in the presence of a specific target, new ligands can be selected that resemble the naturally occurring ones. In this way, new, potentially useful affinity ligands can be generated. Compound libraries-DCL generated by DCC show special interest on a very diverse range of applications: molecular and supramolecular recognition, drug-, catalyst- and material discovery. Kinetic or thermodynamic resolution selfassembly followed by covalent-modification or by crystallization shed light on useful strategies to control and to make convergence between self-organization and functions. [3] Basically, the CDC implements a reversible interface between interacting constituents, mediating the structural self-correlation of different domains of the system by virtue of their basic constitutional behaviours. The self-assembly of the components controlled by mastering supramolecular interactions, may allow the flow of structural information from molecular level toward nanoscale dimensions. Understanding and controlling such up-scale propagation of structural information, might offer the potential to impose further precise order at the mesoscale and new routes to obtain highly ordered ultradense arrays over macroscopic distances. Within this context, during the last decade the CDC is expressing more and more interest for Dynamic Interactive Systems, (DIS). Networks of continuously exchanging and reorganizing reversibly
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