Dynamic contrast-enhanced computed tomography lymphangiography with intranodal injection of water-soluble iodine contras
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EXPERIMENTAL
Dynamic contrast-enhanced computed tomography lymphangiography with intranodal injection of water-soluble iodine contrast media in microminipig: imaging protocol and feasibility Yukichi Tanahashi 1,2 & Ryota Iwasaki 3 & Shinichi Shoda 4 & Hiroshi Kawada 1 & Tomohiro Ando 1 & Masaki Takasu 5 & Fuminori Hyodo 6 & Satoshi Goshima 1,2 & Takashi Mori 5,7 & Masayuki Matsuo 1 Received: 27 December 2019 / Revised: 15 April 2020 / Accepted: 12 June 2020 # European Society of Radiology 2020
Abstract Objectives To evaluate the optimal imaging protocol and the feasibility of intranodal dynamic contrast-enhanced computed tomography lymphangiography (DCCTL) in microminipigs. Methods The Committee for Animal Research and Welfare provided university approval. Five female microminipigs underwent DCCTL after inguinal lymph node injection of 0.1 mL/kg of iodine contrast media at a rate of 0.3 mL/min with three different iodine concentrations: group 1, 75 mgI/mL; group 2, 150 mgI/mL; and group 3, 300 mgI/mL. The CT values of the venous angle, thoracic duct (TD), cisterna chyli, iliac lymphatic duct, and iliac lymph node were measured; increases in CT values pre- to postcontrast were assessed as the contrast-enhanced index (CEI). Multi-detector row CT (MDCT) and volume rendering images showing the highest CEI were qualitatively evaluated. Results The CEI of all lymphatics peaked at 5–10 min. The mean CEI of TD at 10 min of group 2 (193.0 HU) and group 3 (201.5 HU) were significantly higher than that of group 1 (70.7 HU) (p = 0.024). The continuity and overall diagnostic acceptability of all lymphatic system components were better in group 3 (3.6 and 3.0, respectively) than group 1 (2.6 and 1.6) and group 2 (3.0 and 2.6) (p = 0.249 and 0.204). Conclusions The optimal imaging protocol for intranodal DCCTL could be dual-phase imaging at 5 and 10 min after the injection of 300 mgI/mL iodinated contrast media. DCCTL provided good images of lymphatics and is potentially feasible in clinical settings. Key Points • Dynamic contrast-enhanced computed tomography lymphangiography with intranodal injection of water-soluble iodine contrast media showed the highest enhancement of all lymphatics at scan delays of 5 and 10 min. • The optimal iodine concentration for intranodal dynamic contrast-enhanced computed tomography lymphangiography might be 300 mgI/mL. • Intranodal dynamic contrast-enhanced computed tomography lymphangiography provided good images of all the lymphatic system components and is potentially feasible in clinical settings. Keywords Lymphangiography . Lymphatic system . Contrast media . Thoracic duct . Computed tomography
Yukichi Tanahashi and Satoshi Goshima had moved after the study. * Yukichi Tanahashi [email protected]
4
Radiology Service, Gifu University Hospital, Gifu, Japan
5
Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
1
Department of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu 501-1194, Japan
6
Department of Frontier Sci
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