Early compaction at day 3 may be a useful additional criterion for embryo transfer
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ASSISTED REPRODUCTION TECHNOLOGIES
Early compaction at day 3 may be a useful additional criterion for embryo transfer Sébastien Le Cruguel & Véronique Ferré-L’Hôtellier & Catherine Morinière & Sophie Lemerle & Pascal Reynier & Philippe Descamps & Pascale May-Panloup
Received: 31 December 2012 / Accepted: 15 March 2013 / Published online: 7 April 2013 # Springer Science+Business Media New York 2013
Abstract Purpose The reduction of the number of embryos transferred while maintaining a satisfactory rate of pregnancy (PR) with in vitro fertilization calls for a refined technique of embryonic selection. This prospective study investigates the significance of early embryonic compaction at day 3 as a marker of the chances of implantation. Methods We examined 317 transfers and their outcome involving 509 embryos including 91 compacted embryos. Results Early compaction seems linked with the ovarian response to stimulation and embryonic quality. The PR is significantly increased when the embryonic cohort contains at least one compacted embryo (44 % versus 29.5 %, p=0. 01), and when at least one compacted embryo is transferred Contribution for each author SLC and PMP were the principal investigators and take primary responsibility for the paper. PMP and VFH contributed to the conception of design and coordinated the research. CaM, SL and PhD recruited the patients. SLC and PMP contributed to the collection and assembly of data. SLC and PMP contributed to the data analysis and interpretation. SLC and PMP contributed to manuscript writing. PMP, VFH, CaM, SL, PR, and PhD contributed to the drafting of the article, revised it and approved the final version. Capsule Early compaction at day 3 may serve as an additional criterion for embryo selection to improve pregnancy rates in in vitro fertilization. S. Le Cruguel : V. Ferré-L’Hôtellier : P. May-Panloup Laboratoire de Biologie de la Reproduction, Centre Hospitalier Universitaire d’Angers, 49933 Angers cedex 9, France C. Morinière : S. Lemerle : P. Descamps Service de Gynécologie-Obstétrique, Centre Hospitalier Universitaire d’Angers, 49933 Angers cedex 9, France P. Reynier Laboratoire de Biochimie et Biologie Moléculaire, Centre Hospitalier Universitaire d’Angers, 49933 Angers cedex 9, France P. Reynier : P. May-Panloup (*) UMR CNRS 6214-INSERM U771, 49933 Angers cedex 9, France e-mail: [email protected]
(44 % versus 31 %, p
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