Early-phase [ 18 F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury
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ORIGINAL ARTICLE
Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury Leonie Beyer 1 & Alexander Nitschmann 1 & Henryk Barthel 2 & Thilo van Eimeren 3,4,5,6 & Marcus Unterrainer 1 & Julia Sauerbeck 1 & Ken Marek 7,8 & Mengmeng Song 1 & Carla Palleis 9 & Gesine Respondek 9,10 & Jochen Hammes 4 & Michael T. Barbe 5 & Özgür Onur 5 & Frank Jessen 6,11,12 & Dorothee Saur 13 & Matthias L. Schroeter 14,15,16 & Jost-Julian Rumpf 12 & Michael Rullmann 2 & Andreas Schildan 2 & Marianne Patt 2 & Bernd Neumaier 17,18 & Olivier Barret 7,8 & Jennifer Madonia 7,8 & David S. Russell 7,8 & Andrew W. Stephens 19 & Sigrun Roeber 20 & Jochen Herms 10,20 & Kai Bötzel 9 & Johannes Levin 9,10 & Joseph Classen 13 & Günter U. Höglinger 10,21,22 & Peter Bartenstein 1,23 & Victor Villemagne 24,25,26 & Alexander Drzezga 4,6 & John Seibyl 7,8 & Osama Sabri 2 & Matthias Brendel 1,23 Received: 2 January 2020 / Accepted: 24 March 2020 # The Author(s) 2020
Abstract Purpose Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that earlyphase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [18F]PI-2620 as a potential substitute for [18F]fluorodeoxyglucose ([18F]FDG). Methods Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer’s disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson’s disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [18F]PI-2620 tau-PET (0–60 min p.i.) and static [18F]FDG-PET (30–50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R1) of [18F]PI-2620-PET were correlated with corresponding quantification of [18F]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [18F]PI-2620 tau-PETand [18F]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers. Results Highest agreement with [18F]FDG-PET quantification was reached for [18F]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5–2.5 min SUVr & R1) displayed strong agreement in all cortical target regions for global mean (RSUVr 0.76, RR1 = 0.77) and cerebellar normalization (RSUVr 0.68, RR1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [18F]FDG-PET. There were no rele
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