Echocardiography improves prediction of major adverse cardiovascular events in a population with type 1 diabetes and wit
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ARTICLE
Echocardiography improves prediction of major adverse cardiovascular events in a population with type 1 diabetes and without known heart disease: the Thousand & 1 Study Magnus T. Jensen 1,2,3 & Peter Sogaard 4 & Ida Gustafsson 5 & Jan Bech 5 & Thomas F. Hansen 1 & Thomas Almdal 6 & Simone Theilade 2 & Tor Biering-Sørensen 1 & Peter G. Jørgensen 1 & Søren Galatius 5 & Henrik U. Andersen 2 & Peter Rossing 2,7 Received: 26 February 2019 / Accepted: 21 August 2019 # Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract Aims/hypothesis Cardiovascular disease is the most common comorbidity in type 1 diabetes. However, current guidelines do not include routine assessment of myocardial function. We investigated whether echocardiography provides incremental prognostic information in individuals with type 1 diabetes without known heart disease. Methods A prospective cohort of individuals with type 1 diabetes without known heart disease was recruited from the outpatient clinic. Follow-up was performed through Danish national registers. The association of echocardiography with major adverse cardiovascular events (MACE) and the incremental prognostic value when added to the clinical Steno T1D Risk Engine were examined. Results A total of 1093 individuals were included: median (interquartile range) age 50.2 (39.2–60.3) years and HbA1c 65 (56–74) mmol/mol; 53% men; and mean (SD) BMI 25.5 (3.9) kg/m2 and diabetes duration 25.8 (14.6) years. During 7.5 years of followup, 145 (13.3%) experienced MACE. Echocardiography significantly and independently predicted MACE: left ventricular ejection fraction (LVEF)
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