Ectopic Prolactin-Producing Pituitary Adenoma in a Benign Ovarian Cystic Teratoma
- PDF / 349,763 Bytes
- 3 Pages / 595.276 x 790.866 pts Page_size
- 21 Downloads / 180 Views
Ectopic Prolactin-Producing Pituitary Adenoma in a Benign Ovarian Cystic Teratoma Saba Al-Bazzaz & Jason Karamchandani & Eva Mocarski & Eva Horvath & Fabio Rotondo & Kalman Kovacs
# Springer Science+Business Media New York 2014
Abstract We report the presence of pituitary tissue in a benign ovarian cystic teratoma removed surgically from a 43-year-old woman. The pituitary consisted of nontumorous neurohypophysis and adenohypophysis containing mainly prolactin (PRL)-immunopositive cells (80 % of cells) and a small PRL-producing adenoma. The ultrastructure of the tumor cells differed significantly from PRL cells in the nontumorous and adenomatous intrasellar pituitary. It appears that cells differing in ultrastructure from intrasellar pituitary PRL cells can also produce PRL.
Subsequently, Palmer et al. [4] published a case of PRLoma in the wall of an ovarian dermoid cyst causing hyperprolactinemia. We report here the histologic, immunohistochemical, and electron microscopic findings in a benign ovarian cystic teratoma containing PRL-producing endocrine cells removed by surgery from a 43-year-old woman.
Clinical Findings Keywords Pituitary . Ovarian teratoma . PRL . Immunohistochemistry
Introduction Mature cystic teratomas are the most frequent ovarian germ cell tumors in young women [1]. These tumors may contain a variety of different tissues derived from all three germinal layers. Willis described 28 different types of mature tissue that may be found in a teratoma including skin, bone, connective tissue, and cartilage, but pituitary was not mentioned [2]. Russell and Painter [1] were the first to recognize the presence of pituitary tissue in a mature ovarian teratoma. Axiotis et al. [3] reported a corticotroph pituitary adenoma within an ovarian teratoma causing Cushing’s syndrome. S. Al-Bazzaz (*) : J. Karamchandani : E. Horvath : F. Rotondo : K. Kovacs Department of Laboratory Medicine, Division of Pathology, St. Michael’s Hospital, 30 Bond Street, Toronto, ON, Canada M5B 1W8 e-mail: [email protected] E. Mocarski Department of Obstetrics and Gynecology, St. Michael’s Hospital, Toronto, ON, Canada
A 43-year-old G3P3 presented requesting a pelvic ultrasound because of vaginal blood staining after bowel movement. The ultrasound showed a uterus normal in size with a normal endometrial stripe. There were two cysts in the left adnexum each measuring 9 mm. A 3.2-cm complex mass was seen in the right adnexum. Portions of the cyst appeared to be filled with viscous fluid, other areas were echogenic. The differential diagnosis included hemorrhagic cyst and dermoid cyst. Her periods occurred every 2 months with secondary dysmenorrhea of 2 years duration described as being sharp to dull. There was no dyspareunia. On pelvic examination, the uterus was mobile. There was fullness in the right adnexum which was mobile. No nodularity was noted. The ultrasound was repeated after 3 months. The left ovary had a physiological follicle. The right ovary measured 4.5× 4.1×2.9 cm and was occupied by a hypoechoic lesion with echogeni
Data Loading...
