Effect of different treatments on recurrent aphthous stomatitis: laser versus medication
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ORIGINAL ARTICLE
Effect of different treatments on recurrent aphthous stomatitis: laser versus medication Xiao Huo 1 & Ning Han 1 & Li Liu 1 Received: 29 February 2020 / Accepted: 21 October 2020 # Springer-Verlag London Ltd., part of Springer Nature 2020
Abstract Recurrent aphthous stomatitis (RAS) is a common disease with ulcers in oral cavity which may trigger chewing, speaking, and swallowing difficulties to patients. Treatment of RAS is primarily aimed at pain relief and the promotion of wound healing. However, few agents have been found to have definite effect in the management of RAS and most of the medicinal products may cause adverse reactions or other disadvantages, which makes their clinical usage questionable. The purpose of this randomized controlled clinical trial (RCT) was to assess the clinical effect of diode laser and traditional medication treatment on RAS. In this study, 56 patients were randomly assigned to two groups (n = 28). Laser group was treated using diode laser (810 nm, 1.0 W, CW, irradiation time 20 s for 3 applications) once daily for continuous 3 days. Medication group was treated with triamcinolone acetonide 0.1% three times a day until the lesion was healed. Spontaneous and functional pain level on the third day of treatment was significantly less in the laser group. Significant difference was observed with respect to healing time; however, the order of difference is small albeit of statistical significance. Diode laser with the chosen parameters had better effects on pain relief and no distinct advantage on wound healing comparing with medication. Trial registration number: ChiCTR2000030298; date of registration: 26 February 2020 (retrospectively registered) Keywords Recurrent aphthous stomatitis . Photobiomodulation . Low level laser therapy . Pain . Wound healing
Introduction Recurrent aphthous stomatitis (RAS) is a common and frequently encountered disease which develops recurrently, with painful ulcers confined in oral cavity only as clinical manifestation [1]. The ulcers are typically clearly defined, sunken in the central part, round or elliptical in shape, circumscribed by erythematous haloes, and covered by pseudomembrane tissues with grey or yellow in color [2]. RAS is generally identified as three different types respectively named Minor * Li Liu [email protected] Xiao Huo [email protected] Ning Han [email protected] 1
Department of Oral Medicine, School and Hospital of Stomatology, Hebei Medical University & Hebei Key Laboratory of Stomatology, No. 383, Zhongshan East Road, Chang’an District, Shijiazhuang City 050017, Hebei Province, China
(MiRAS), Major (MaRAS), and Herpetiform (HU) ulcers according to the distinct discrepancy primarily in morphology and prognosis of ulcers [3]. Thereinto, minor aphthous is the most prevalent form which accounts about 70–85% of all RAS lesions [4]. The definite etiology and pathophysiology of RAS remain unclear up to date. However, it is considered to be a kind of multifactorial disease. Predisposing factors like immune system dysf
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