Effect of Gliclazide or Gliclazide plus Metformin Combination on Glycemic Control in Patients with T2DM in India: A Real
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ORIGINAL RESEARCH ARTICLE
Effect of Gliclazide or Gliclazide plus Metformin Combination on Glycemic Control in Patients with T2DM in India: A Real‑World, Retrospective, Longitudinal, Observational Study from Electronic Medical Records Nareen Krishna Polavarapu1 · Ravindra Kale1 · Bipin Sethi2 · R. K. Sahay3 · Uday Phadke4 · Santosh Ramakrishnan5 · Amey Mane1 · Suyog Mehta1 · Snehal Shah6
© The Author(s) 2020
Abstract Background The efficacy of gliclazide has been reported in clinical trials in India. However, real-world data on the effectiveness of gliclazide in India is unavailable. Objective To provide real-world evidence regarding the effectiveness of gliclazide or gliclazide + metformin fixed-dose combination or separate medications, used either as monotherapy or as the latest add-on to other antihyperglycemic agents in reducing glycated hemoglobin (HbA1c) levels in Indian patients with type 2 diabetes mellitus (T2DM). Methods Electronic medical record data of adult patients who were diagnosed with T2DM who were newly initiated on or had been prescribed gliclazide or gliclazide + metformin combination for 7% was − 0.8% (− 1.26, − 0.34) in gliclazide only group; − 1.6% (− 1.89, − 1.31; p
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