Effect of Lactobacillus brevis CD2 containing lozenges and plaque pH and cariogenic bacteria in diabetic children: a ran
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ORIGINAL ARTICLE
Effect of Lactobacillus brevis CD2 containing lozenges and plaque pH and cariogenic bacteria in diabetic children: a randomised clinical trial Stefano Lai 1 & Peter Lingström 2 & Maria Grazia Cagetti 3 & Fabio Cocco 4 Maria Antonietta Arrica 4 & Guglielmo Campus 4,5,6,7,8
&
Gianfranco Meloni 4 &
Received: 18 September 2019 / Accepted: 12 May 2020 # The Author(s) 2020
Abstract Objective The short-term effect (60 days) of Lactobacillus brevis CD2 lozenges vs placebo on variables related to caries and gingivitis in type 1 diabetic children was evaluated. Material and methods Eight diabetics (4–14 years old) were assigned to two groups (n = 34 subjects each), probiotic lozenges and placebo. Stimulated saliva for microbiological analysis and plaque pH were assessed at baseline (t0), 30 days (t1), 60 days (t2) and in the follow-up period (90 days from baseline, t3). Gingival status was assessed at t0, t2 and t3. Two-way ANOVA assessed differences between groups. Results In the probiotic group, Streptococcus mutans bacterial density mean scores dropped from 3.11 ± 1.13 at baseline to 1.82 ± 0.72 (t2) and to 2.06 ± 0.56 (t3), while in the placebo group, the scores were 3.09 ± 0.8 (t0), 2.82 ± 0.47 (t2) and 3.11 ± 0.43 (t3) (p < 0.01). Lowest and maximum pH fall increased in the probiotic group, from 5.37 ± 0.41 at baseline to 5.49 ± 0.24 at t3 (p < 0.01) and from 1.20 ± 0.46 to 0.98 ± 0.29 (p = 0.02). Bleeding score decreased significantly in both groups, showing a statistically significant lower bleeding score at t2 in the probiotic group (25.6%, 95% CI 21.5–32.7 vs 29.5%, 95% CI 25.2–34.9, p = 0.02). Conclusions Lactobacillus brevis CD2 has shown to improve caries-related risk factors and gingival health in diabetic children. Clinical relevance Lactobacillus brevis CD2 might contribute to improved oral health in type 1 diabetic children. Keywords Probiotic . Lactobacillus brevis CD2 . Caries . Plaque pH . Salivary mutans streptococci . Children
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00784-020-03342-0) contains supplementary material, which is available to authorized users. * Fabio Cocco [email protected] 1
Department of Biomedical Sciences-Medical School, University of Sassari, Sassari, Italy
2
Department of Cariology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
3
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy
4
Department of Surgery, Medical and Experimental Sciences, University of Sassari, Sassari, Italy
5
Department of Restorative, Preventive and Pediatric Dentistry, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland
6
Präventivzahnmedizin und orale Epidemiologie der Lutz Zürrer Stiftung, Klinik für Zahnerhaltung, Präventiv- und Kinderzahnmedizin, Zahnmedizinische Kliniken (ZMK), Universitär Bern, Freiburgstrasse 7, 3010 Bern, Switzerland
7
Department of Surgery, Microsurgery and Medicine Sciences, School of Dentistry, Univer
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