Effect of mesoporous characteristics on competitive adsorption kinetics of uremic-like toxin and atorvastatin on spheric
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ORIGINAL CONTRIBUTION
Effect of mesoporous characteristics on competitive adsorption kinetics of uremic-like toxin and atorvastatin on spherical carbon adsorbents for an in vitro chronic renal failure therapeutic model Yayoi Nitta 1 & Yusuke Hattori 1 & Makoto Otsuka 1 Received: 1 April 2020 / Revised: 19 July 2020 / Accepted: 6 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Indole-3-acetic acid (IA, urine-like toxin) coexisting with atorvastatin (AT) was adsorbed by spherical carbonaceous adsorbents (SCs). The relationship between the competitive adsorption kinetics and the mesoporous structures was investigated. The pore structures of the four SCs were analyzed using the Hg and gas adsorption methods. SC adsorption tests were performed using the dissolution test with the paddle method with an SC sample in distilled water containing IA and/or AT at 37.0 °C. The amounts of IA and AT adsorbed on SCs in single- and binary-drug administration tests were measured based on the ultraviolet-visible spectra using classical least squares analysis. Rate constants for the drug adsorption of IA and AT by SCs (kIA and kAT, respectively) were suppressed by the effect of coexisting drugs. The suppression of IA adsorption by the coexisting drug was dependent on the pore structure of the SCs. kIA and kAT against the SCs were competitively inhibited by coexisting drugs. Keywords Spherical carbonaceous adsorbent . Competitive adsorption kinetics . Mesoporous structures . Indole-3-acetic acid . Atorvastatin
Introduction Currently, there is an active ongoing research effort focusing on the removal of toxic chemicals in wastewater by adsorption for environmental protection [1]. In particular, sewage from pharmaceutical plants contains various harmful chemical substances and has negative effects on the environment [2]. Zeolites, clays, polymers, activated carbon, soils, and various types of composites are the most important materials for the removal of toxic chemicals and pharmaceuticals from natural and biological environments. Previous studies have reported on the effectiveness of activated carbon–based adsorption techniques for the removal of drugs and their metabolites from drug-contaminated sewage [3]. However, most of these reported studies have focused on the ability of the material to adsorb compounds from single-component solutions [4], while only a few studies have been conducted for the removal
* Makoto Otsuka [email protected] 1
Faculty of Pharmacy, Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishi-Tokyo, Tokyo 202-8585, Japan
of pharmaceuticals from sewage contaminated with twocomponent pharmaceuticals using activated carbon adsorption technology [5]. In particular, competitive adsorption of drugs in single- and/or binary-drug solutions (ibuprofen and amoxicillin) used as model wastewater was investigated by equilibrium and dynamic drug adsorption tests [6]. Activated carbon adsorbs the most toxic substances and can be quickly removed
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