Effect of neuroprotective citicoline eye drops on macular microcirculation
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ORIGINAL PAPER
Effect of neuroprotective citicoline eye drops on macular microcirculation Esat Cinar
. Berna Yuce
. Fatih Aslan
. Go¨khan Erbakan
Received: 21 January 2020 / Accepted: 27 April 2020 Ó Springer Nature B.V. 2020
Abstract Background and objective To use optical coherence tomography (OCTA) examination of the retinal microvascular structures to evaluate the effect of neuroprotective eye drops (citicoline, OMK1Ò) administered for laser in situ keratomileusis (LASIK) surgery. Patients and methods This prospective study included 45 patients treated with citicoline after LASIK and 48 patients not treated with citicoline after LASIK as a control group. In both groups, the foveal avascular zone (FAZ), retinal superficial vascular density (SVD), and deep vascular density (DVD) in the foveal and parafoveal areas were measured
E. Cinar (&) G. Erbakan Department of Ophthalmology, Ekol Eye Hospital, 8019/ 13 Str. No: 2 C¸igli, Izmir, Turkey e-mail: [email protected]
preoperatively and at 1 and 3 months postoperatively using OCTA. Results No significant difference was detected between the groups in terms of preoperative SVD or DVD in the foveal and parafoveal zones and all quadrants (superior, inferior, temporal, and nasal) (P [ 0.05). Similarly, no significant difference was detected between the citicoline group and control group in terms of SVD or DVD in the foveal and parafoveal zones at 1 and 3 months after LASIK (P [ 0.05). Conclusions Despite their neuroprotective effect, topical citicoline drops had no significant effect on the superficial and deep microvascular structures of the retina or choriocapillaris. Keywords Citicoline Optical coherence tomography angiography Retinal microvascular structure Neuroprotection Laser in situ keratomileusis
G. Erbakan e-mail: [email protected] B. Yuce Tepecik Training and Research Hospital Ophthalmology Clinic, University of Health Sciences, Izmir, Turkey e-mail: [email protected] F. Aslan Department of Ophthalmology, Alaaddin Keykubat University, Alanya, Antalya, Turkey e-mail: [email protected]
Introduction Citicoline (cytidine-5-diphosphocholine) is an important endogenous molecule involved in phospholipid biosynthesis. As part of the phospholipid structure, citicoline comprises a major component of all biological membranes [1, 2].
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Int Ophthalmol
Some clinical studies have also suggested that citicoline may be useful in the treatment of traumatic brain injuries, Parkinson’s disease, ischemic stroke, Alzheimer’s disease, cerebral hypoxic neuronal damage, and glaucoma [2–7]. Refractive surgical procedures are popular operations that provide emmetropization. However, procedures such as epikeratophakia, radial keratotomy, laser photorefractive keratectomy, and laser in situ keratomileusis (LASIK) have been associated with reduced corneal sensitivity postoperatively [8, 9]. One of our recent studies demonstrated that corneal sensitivity recovered approximately 2 weeks earlier with citico
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