Effect of periosteal reaction in medication-related osteonecrosis of the jaw on treatment outcome after surgery
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ORIGINAL ARTICLE
Effect of periosteal reaction in medication‑related osteonecrosis of the jaw on treatment outcome after surgery Sakiko Soutome1 · Souichi Yanamoto2 · Misa Sumi3 · Saki Hayashida2 · Yuka Kojima4 · Shunsuke Sawada4 · Satoshi Rokutanda5 · Hiroshi Iwai6 · Toshiyuki Saito1 · Masahiro Umeda2 Received: 21 April 2020 / Accepted: 28 August 2020 © The Japanese Society Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2020
Abstract Introduction Surgical treatment in patients with medication-related osteonecrosis of the jaw (MRONJ) is superior to conservative treatment. However, treatment outcome in patients with periosteal reaction (PR) was significantly poorer than that of those without PR. The purpose of this retrospective study was to analyze the pathophysiology and clinical significance of PR in MRONJ. Materials and methods Out of 181 patients with MRONJ undergoing surgery, 38 patients with PR were enrolled in the study. CT examinations, histological examinations, and bacteriological examinations using real-time polymerase chain reaction were performed, and the relationship among the opted surgical method, CT findings, and treatment outcome was investigated. Results The pattern of PR was classified into three types: type 1, new bone is formed parallel to the mandible, and no gap was evident between the mandible and new bone; type 2, new bone is formed parallel to the mandible, and a gap was evident between them; type 3, an irregular shape. Histological examinations revealed inflammatory tissue in the area visualized as a gap on CT. Bacteriological examination showed the presence of bacteria in the type 2 or type 3 PR. Complete cure was observed in 21 of 38 (55.3%) patients, which was lower than the cure rate of 73.4% in 143 patients without PR. The cure rate was significantly lower in cases with type 3 PR or with persistent osteolysis. Conclusions It seems that complete resection of both osteolytic area and type 3 PR is necessary to obtain complete healing in patients undergoing marginal mandibulectomy. Keywords Antiresorptives · Radiology · Dental biology · Clinical trials · Osteoporosis
Introduction * Souichi Yanamoto syana@nagasaki‑u.ac.jp 1
Department of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
2
Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1‑7‑1 Sakamoto, Nagasaki 852‑8588, Japan
3
Department of Radiology and Cancer Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
4
Department of Dentistry and Oral Surgery, Kansai Medical University Hospital, Osaka, Japan
5
Department of Dentistry and Oral Surgery, Juko Memorial Nagasaki Hospital, Nagasaki, Japan
6
Department of Otorhinolaryngology, Head and Neck Surgery, Kansai Medical University, Osaka, Japan
Antiresorptive agents, such as bisphosphonate and denosumab, are usually first-choice drugs for patients with osteoporosis, malignant tumors with bone metastasis, and m
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