Effect of Rectal Ozone (O 3 ) in Severe COVID-19 Pneumonia: Preliminary Results
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COVID-19
Effect of Rectal Ozone (O3) in Severe COVID-19 Pneumonia: Preliminary Results Marcos Edgar Fernández-Cuadros 1,2 & María Jesús Albaladejo-Florín 1 & Sandra Álava-Rabasa 1 & Isabel Usandizaga-Elio 3 & Dolores Martinez-Quintanilla Jimenez 4 & Daiana Peña-Lora 5 & Inmaculada Neira-Borrajo 6 & María Jesús López-Muñoz 7 & Javier Rodríguez-de-Cía 8 & Olga Susana Pérez-Moro 1 Accepted: 20 June 2020 # Springer Nature Switzerland AG 2020
Abstract The aim of this study is to evaluate the effectiveness of rectal ozone (O3) in COVID-19 patients with severe pneumonia admitted at Hospital Universitario Santa Cristina, Madrid. In a before-and-after study, four patients admitted with severe bilateral pneumonia due to COVID-19 were treated with rectal ozone and confirmed with (+) RT-PCR for SARS-CoV-2 and evaluated afterwards. The analyzed outcome variables were as follows: (a) clinical improvement (O2 saturation and O2 supply); (b) biochemical improvement (fibrinogen, D-dimer, urea, ferritin, LDH, IL-6, and CRP); (c) radiological improvement. The treatment protocol consisted of 5 sessions (1 session/day) of intra-rectal ozone, applied in a volume of 100 mL and a concentration of 35 μg/mL. The Protocol was previously approved by the Hospital’s Health Care Ethics Committee (CEAS) (Report 15/4/2020) for compassionate use in the face of this exceptional pandemic situation, and prior informed consent was obtained from the patient/legal representative. The patients improved oxygen saturation, as observed by the lower number of desaturations and the lower supply of O2. Biomarkers of inflammation decreased (fibrinogen, D-dimer, urea, ferritin, LDH, IL-6, and CRP). Finally, the radiological signs of bilateral viral pneumonitis improved between 1 and 2 grades based on Taylor’s radiological scale. Rectal ozone decreases O2 supply and improves O2 saturation, decreases inflammation biomarkers, and improves Taylor’s radiological grade in patients with severe COVID-19 pneumonia. Rectal ozone is a safe, effective, cheap, and simple alternative capable of acting on the SARS-CoV-2 virus, and it is presented as an adjunctive therapeutic option to consider in the management of severe bilateral COVID-19 pneumonia. Keywords Ozone . Ozone therapy . Pneumonia . COVID-19 . SARS-CoV-2
Introduction The World Health Organization (WHO) on March 11th, 2020 has declared that we are in an exceptional situation of
pandemic due to the new SARS-CoV-2 or COVID-19 virus (https://www.who.int/es/dg/speeches/detail/who-directorgeneral-s-opening-remarks-at-the-media-briefing-on-covid19%2D%2D-11-march-2020).
This article is part of the Topical Collection on Covid-19 * Marcos Edgar Fernández-Cuadros [email protected]; [email protected] 1
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Servicio de Rehabilitación y Medicina Física, Hospital Universitario Santa Cristina, Madrid, Spain Servicio de Medicina Física y Rehabilitación, Hospital Universitario Santa Cristina, Calle del Maestro Vives 2 y 3, CP28009 Madrid, Spain Servicio de Medicina Interna, Hospital Universitario Santa
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