Effect of sarcopenia on short- and long-term outcomes in patients with gastric neuroendocrine neoplasms after radical ga
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RESEARCH ARTICLE
Open Access
Effect of sarcopenia on short- and longterm outcomes in patients with gastric neuroendocrine neoplasms after radical gastrectomy: results from a large, twoinstitution series Jia-bin Wang1,2,3†, Zhen Xue1,2,3†, Jun Lu1,2,3†, Qing-liang He4†, Zhi-fang Zheng1,2,3, Bin-bin Xu1,2,3, Jian-wei Xie1,2,3, Ping Li1,2,3, Yu Xu5, Jian-xian Lin1,2,3, Qi-yue Chen1,2,3, Long-long Cao1,2,3, Mi Lin1,2,3, Ru-hong Tu1,2,3, Ze-ning Huang1,2,3, Ju-li Lin1,2,3, Chang-ming Huang1,2,3 and Chao-hui Zheng1,2,3*
Abstract Background: The relationship between sarcopenia and the prognoses of patients with gastric neuroendocrine neoplasms (g-NENs) is unclear. This study was designed to explore the effects of sarcopenia on short-term and long-term outcomes of patients with g-NENs after radical gastrectomy. Methods: This study retrospectively collected data from 138 patients with g-NENs after radical gastrectomy. The skeletal muscle index (SMI) diagnostic threshold for sarcopenia was determined using X-tile software. Cox regression analyses were performed to determine the independent risk factors for 3-year overall survival (OS) and 3year recurrence-free survival (RFS). (Continued on next page)
* Correspondence: [email protected] † Jia-bin Wang, Zhen Xue, Jun Lu and Qing-liang should be considered cofirst authors. 1 Department of Gastric Surgery, Fujian Medical University Union Hospital, No.29 Xinquan Road, Fuzhou 350001, Fujian Province, China 2 Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Wang et al. BMC Cancer
(2020) 20:1002
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Results: In this study, 59 patients (42.8%) were diagnosed with sarcopenia. Among patients in the sarcopenia group and nonsarcopenia group, the incidences of total postoperative complications were 33.9 and 30.4%, incidences of serious postoperative complications were 0 an
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