Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals
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ARTICLE
Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes: a secondary analysis of a randomised clinical trial Mette Y. Johansen 1 & Kristian Karstoft 1,2 & Christopher S. MacDonald 1,3 & Katrine B. Hansen 1,4 & Helga Ellingsgaard 1 & Bolette Hartmann 5,6 & Nicolai J. Wewer Albrechtsen 5,7,8 & Allan A. Vaag 4 & Jens J. Holst 5,6 & Bente K. Pedersen 1 & Mathias Ried-Larsen 1 Received: 3 May 2020 / Accepted: 3 July 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Aims/hypothesis The aim was to investigate whether an intensive lifestyle intervention, with high volumes of exercise, improves beta cell function and to explore the role of low-grade inflammation and body weight. Methods This was a randomised, assessor-blinded, controlled trial. Ninety-eight individuals with type 2 diabetes (duration
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