Efficacy of a wound-dressing biomaterial on prevention of postinflammatory hyperpigmentation after suction blister epide
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ORIGINAL PAPER
Efficacy of a wound‑dressing biomaterial on prevention of postinflammatory hyperpigmentation after suction blister epidermal grafting in stable vitiligo patients: a controlled assessor‑blinded clinical study with in vitro bioactivity investigation Ziqi Liu1 · Min Jiang1 · Juemin Zhao1 · Qianqian Wang1 · Chengfeng Zhang1 · Min Gao2 · Ming Gu2 · Leihong Xiang1 Received: 18 September 2019 / Revised: 3 February 2020 / Accepted: 12 February 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Postinflammatory hyperpigmentation (PIH) is a common disfiguring complication following inflammatory dermatoses and cosmetic procedures in dark-skinned individuals. Anti-inflammatory and repairing agents targeting primary inflammation and injury are becoming promising choices for preventing PIH. The aim of this active-controlled, assessor-blinded, intraindividual monocentric study was to evaluate the preventive effect of a wound-dressing biomaterial, mussel adhesive protein (MAP) in the suction blister-induced PIH model. Twenty Chinese patients underwent suction blister epidermal grafting had defined wound areas to receive a topical MAP spray or a potent corticosteroid cream once daily for seven consecutive days after operation. In situ semi-quantitative evaluations of inflammation and pigmentation were achieved by Mexameter, reflectance confocal microscopy and dermoscopy on week 1, week 4, and week 12. Topical application of MAP exerted remarkably inhibitory effect on PIH comparable to fluticasone propionate, manifested as significantly lower melanin index and papillary contrast measured by Mexameter and confocal microscopy on week 12 compared to untreated sites. Although MAP exhibited moderate anti-inflammatory effect weaker than fluticasone propionate, MAP-treated sites healed faster than steroidtreated and untreated sites. The biological activity of MAP was further studied in UVB-irradiated HaCaT cell model, which revealed MAP decreased the expression of UVB-induced α-melanocyte stimulating hormone (α-MSH) and pro-inflammatory cytokines (IL-1α, IL-6, COX-2). It also protected HaCaT cells from UVB-induced cell death and apoptosis. In conclusion, MAP could be a novel postoperational wound dressing preventing PIH associated with skin inflammation and injury. Keywords Inflammation · Pigmentation · Wound healing · Mussel adhesive protein · Confocal microscopy · Ultraviolet B
Introduction Postinflammatory hyperpigmentation (PIH) is a common sequela following cutaneous inflammation in dark-skinned individuals [1]. It occurs after various inflammatory dermatoses and dermatologic procedures, affecting physical Ziqi Liu, Min Jiang, Juemin Zhao should be considered joint first author. * Leihong Xiang [email protected] 1
Department of Dermatology, Huashan Hospital, Fudan University, No. 12th Middle Wulumuqi Road, Shanghai 200040, China
USUN Biochemical Technology Co., Ltd., Jiangyin, China
2
appearance and treatment compliance. Although PIH was regarded as a self-limiting complicati
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