Efficacy of Interleukin-1 Targeting Treatments in Patients with Familial Mediterranean Fever
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Efficacy of Interleukin-1 Targeting Treatments in Patients with Familial Mediterranean Fever Pinar Cetin,1 Ismail Sari,1,4 Betul Sozeri,2 Ozlem Cam,2 Merih Birlik,1 Nurullah Akkoc,1 Fatos Onen,1 and Servet Akar3
Abstract—Herein, we reported our experience in colchicine-resistant familial Mediterranean fever (FMF) patients who are treated with anti-interleukin-1 (IL-1) drugs. A retrospective review of medical records of anti-IL-1 recipients was performed. The main clinical characteristics of these patients and the evolution after anti-IL-1 were recorded. There were 20 patients (11 male [M] and 9 female [F]). Despite regular colchicine treatment, median number of attacks per month and per year was 1 (1–4) and 12 (4– 50), respectively. Twelve patients were receiving anakinra, and eight patients were treated with canakinumab. The number of monthly and yearly attacks after IL-1 treatment was significantly decreased after the biologic agent (p
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